Brief Answer: combination therapy Detailed Answer: Hello XXXXXXX The best pain medicine for a gout flare would be a combination therapy. This can be a combination of drugs like colchicine plus NSAIDs, or oral corticosteroids plus colchicine, or intra-articular steroids plus colchicine or NSAIDs. It all depends on how you respond to the treatment. Ultimately, the aim of treatment would be to terminate an acute flare and obtain maximum pain relief. In the NSAIDs group, indomethacin, naproxen and celecoxib are commonly used. In oral steroids, prednisone is routinely used to abort an attack. Your treating doctor could decide on the best medicine for you depending on your response to these drugs, and weighing the risk benefit ratio of using these drugs. Hope this helps you. Regards,

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