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What Does An Indeterminate Result On The Western Blot Indicate?

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Posted on Fri, 18 Sep 2015
Question: My friend tested indeterminate result of western blott twice. What will be the expected outcome? She is a woman with two kids.
doctor
Answered by Dr. Sheetal Verma (1 hour later)
Brief Answer:
I need to know few things.

Detailed Answer:
Hi
Thanks for your query at HCM
I understand your concern and situation.

I would like to know that have you got the HIV RNA or DNA PCR test or 4 th generation ELISA test?
I would be better able to guide you.

Dr Sheetal Verma




Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Sheetal Verma (5 hours later)
she got rapid test and western blot. At first reactive and the second one is non reactive. The result its indeterminate. What probably the result if she will be given RNA test and CD4 count?
doctor
Answered by Dr. Sheetal Verma (2 minutes later)
Brief Answer:
Need further tests for confirmation.

Detailed Answer:
Well come back.

I understand your concern. I would suggest you that you must get her 4 th generation ELISA test and HIV PCR test done. These 2 tests will guide us better regarding the disease if Western blotting is indeterminate. No need of CD4 counts as of now.

Take care.
Above answer was peer-reviewed by : Dr. Raju A.T
doctor
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Follow up: Dr. Sheetal Verma (2 hours later)
If its indeterminate, what usually will be the result next will be positive? Is there a big chance that it will come out as negative?
doctor
Answered by Dr. Sheetal Verma (4 hours later)
Brief Answer:
Chances of positivity is more.

Detailed Answer:
Hi
I would like to you what that means. The indeterminate results suggest that patient is probably early on in infection, so the tests are not showing completely yet. So the chances of positivity is definitely higher. But I suggest you to follow up after PCR results.

Stay Optimistic..
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Above answer was peer-reviewed by : Dr. Sonia Raina
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Answered by
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Dr. Sheetal Verma

Infectious Diseases Specialist

Practicing since :2001

Answered : 635 Questions

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What Does An Indeterminate Result On The Western Blot Indicate?

Brief Answer: I need to know few things. Detailed Answer: Hi Thanks for your query at HCM I understand your concern and situation. I would like to know that have you got the HIV RNA or DNA PCR test or 4 th generation ELISA test? I would be better able to guide you. Dr Sheetal Verma