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What Does Absence Of Corpus Callosum In The Fetus Indicate?

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Posted on Tue, 8 Jul 2014
Question: I am carrying twins....I have been told that one twin may be missing her corpus callosum....there is so much info on the internet....still waiting for apt, can you provide any info about possible outcome...
doctor
Answered by Dr. Sudhir Kumar (34 minutes later)
Brief Answer:
Developmental delay and seizures may occur.

Detailed Answer:
Hi,

Thank you for posting your query.

I have noted the details about the likely absence of corpus callosum in one of the twins.

The outcome in a baby with absence of corpus callosum is highly variable, so, a clear cut prediction of possible neurological outcome is difficult.

The baby may be neurological normal in some cases. However, several children with absence of corpus callosum have developmental delay and seizures.

I hope my answer helps. Please get back if you have any follow up queries or if you require any additional information.

Wishing you good health,

Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist
Apollo Hospitals, XXXXXXX XXXXXXX
Click on this link to ask me a DIRECT QUERY: http://bit.ly/Dr-Sudhir-kumar
My BLOG: http://bestneurodoctor.blogspot.in


Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (1 hour later)
What follow up questions should I ask my doctor? Are these delays usually serious? I have read that some people opt to not continue to carry baby with this issue....I don't feel that is an option for me for am terrified of a horrible outcome and a baby without a relatively normal quality of life. I meant that not carrying the baby to term was not an option for me....don't think that came across correctly.

But have read that these babies may never walk or talk or be independent at all?

Is it possible that CSP/corpus callosum wasn't visable to due baby being small for gestational age or being in a bad position?
doctor
Answered by Dr. Sudhir Kumar (6 hours later)
Brief Answer:
Yes, it is possible.

Detailed Answer:
Thank you for getting back.

It is possible that CSP/corpus callosum was not visible. This can be further clarified by the sonologist (radiologist). A repeat scan may be useful.

It is very difficult to predict the outcome as it is highly variable. If you have decided to continue carrying the baby, it is better to hope for a positive outcome, as several babies have relatively minor developmental issues.

Best wishes,
Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (5 days later)
I went for a follow up sonogram

They said that they believe that they can see the corpus callosum, it's just hard to see because baby is small. Other structures in the back of the brain look small as well....they are sending me for an MRI....is it ok if structures are there but small?

What is prognosis?

Also, the lateral ventricles are still dialated, two weeks ago they were 1.06 and 1.07, now they are 1.11 and 1.12, is this a large increase

How will this effect neuro development? is there any chance for a normal outcome?
doctor
Answered by Dr. Sudhir Kumar (7 minutes later)
Brief Answer:
Good news!

Detailed Answer:
Thank you for getting back with good news.

Seeing corpus callosum is a very good news. A child with small corpus callosum would have a much better outcome than that of a child without corpus callosum.

MRI would be better for accurate diagnosis.

The increase in ventricle size is minor.

There are some chances of near normal development.

Best wishes,
Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Sudhir Kumar (5 minutes later)
Is it possible that corpus callosum and other brain structures are small because baby is small? She is only in the 11% percentile and being watched for IUGR as well.

What other structures are they going to look for?

From what I have read, if ventricles continue to get larger that is bad, do they ever go back down in size?
doctor
Answered by Dr. Sudhir Kumar (6 hours later)
Brief Answer:
Yes, it is possible.

Detailed Answer:
Thank you for getting back.

Yes, it is possible that brain structures are small partly because of IUGR. We expect growth to pick up later on.

There is nothing specific, but cerebral cortex, cerebellum and brainstem are other important structures they would look for in the MRI.

As the brain volume increases, ventricle size may decrease.

Best wishes,
Dr Sudhir Kumar MD DM (Neurology)
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Sudhir Kumar

Neurologist

Practicing since :1994

Answered : 6232 Questions

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What Does Absence Of Corpus Callosum In The Fetus Indicate?

Brief Answer: Developmental delay and seizures may occur. Detailed Answer: Hi, Thank you for posting your query. I have noted the details about the likely absence of corpus callosum in one of the twins. The outcome in a baby with absence of corpus callosum is highly variable, so, a clear cut prediction of possible neurological outcome is difficult. The baby may be neurological normal in some cases. However, several children with absence of corpus callosum have developmental delay and seizures. I hope my answer helps. Please get back if you have any follow up queries or if you require any additional information. Wishing you good health, Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist Apollo Hospitals, XXXXXXX XXXXXXX Click on this link to ask me a DIRECT QUERY: http://bit.ly/Dr-Sudhir-kumar My BLOG: http://bestneurodoctor.blogspot.in