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What Does HBSAG Of .99 Indicate?

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Posted on Sat, 13 Sep 2014
Question: Hi my result of hbsag is 1.08 then we.repeat the test and it became 0.99 the machine we used is architect.. And we also do test kit screening and im negative, what does it mean.. Please help me..
doctor
Answered by Dr. Matin Ahmad Khan (2 hours later)
Brief Answer:
These are signal per cutoff (s/c) values

Detailed Answer:
Hi, Thanks for your question. I am Dr Matin , answering your question.

HBsAg is also called Surface Antigen or Australia Antigen.
Hepatitis B virus (HBV) tests check for substances in the blood that show whether a hepatitis B infection is active or has occurred in the past. The tests look for different signs of infection (markers) which may be -- antigens, antibodies or the genetic material(DNA) of the virus itself and the genetic material of Hepatitis B is DNA.

As antigens are markers made by bacteria or viruses so the presence of HBV antigens means that the virus is in the body and HBsAg is one of the three antigens of HBV found in the blood. Now the
results of HBV serologic markers are reported qualitatively or quantitatively as international units (IU) or signal per cutoff (s/c) values. For example, a hepatitis B surface antigen (HBsAg) level of less than 1 s/c may be considered negative, while a level more than 5 s/c is considered positive. Any value between 1 and 5 s/c is indeterminate and should be repeated. So here > 5 s/c value is a cut off value and below this is negative and above this value is a positive result .
So your s/c values of two tests (1.08 and 0.99) would have been definitely be lower than a cut off value written in the result report to declare you a negative for Hep B .

Moreover there is no standardization between laboratories, and these cutoff values tend to vary between manufacturers. Therefore, results are usually reported as “negative” or “positive.” as per the information from the laboratory or manufacturer’s insert, which is always referenced for quantitative measurement.
So I guess your cut off value mentioned in your report must be less than the values you quoted to have declared you as a 'Negative ' for HBsAg. So don't worry, you are not positive .
Hope it helps.
Keep healthy and be happy.
Regards



Above answer was peer-reviewed by : Dr. Yogesh D
doctor
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Follow up: Dr. Matin Ahmad Khan (1 hour later)
but doctor, my SgPT is elevated, i got 81.. but my bilirubin is normal all liver function test is normal except sgot and sgpt.. do i need to confirm my core antigen in this case?
doctor
Answered by Dr. Matin Ahmad Khan (53 minutes later)
Brief Answer:
Don't worry

Detailed Answer:
Thanks for your response. I guess you seem too worried.

Of course your SGPT is raised but is a mild one and it is considered significantly raised only when it is elevated up to x 3-10 times the normal limit. Your SGOT too, I guess too might be mildly raised .

Isolated cases of elevation of liver enzymes may be there in 2.5 % of normal population.

Core antigen can't be measured, only antibodies against it can be and that too core antigens do have a rationale to be done (only when HBsAg is positive - in your case HBsAg is negative , so the antibodies against core antigens are not warranted )

Total hepatitis B core antibody (anti-HBc) which appears at the onset of symptoms in acute hepatitis B and persists for life. The presence of anti-HBc indicates previous or ongoing infection with hepatitis B virus in an undefi ned time frame

IgM antibody to hepatitis B core antigen (IgM anti-HBc) -its positivity indicates recent infection with hepatitis B virus (<6 mos). Its presence indicates acute infection

You have not mentioned the reason why the LFTs (Liver function tests )were done for in your case? I mean, what were problems/risk factors that lead to Liver Biochemical investigations? Were there any?

My advice in your scenario is to repeat your LFTs after 3 months and see a Liver Specialist if they continue to remain deranged .

Hope this helps.
Regards

Above answer was peer-reviewed by : Dr. Vaishalee Punj
doctor
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Follow up: Dr. Matin Ahmad Khan (1 hour later)
thanks doctor, honestly im so worried right now.. im working as a medical laboratory technologist, and we just screened our blood and run some test just to see if what the result is.. and thats the result i came up.. i just only want to confirm if i have hepatitis B, because my screening is in borderline.. because as i remember my last shot of vaccine happened early last year.. hope you can help me to know what to do..
doctor
Answered by Dr. Matin Ahmad Khan (6 hours later)
Brief Answer:
No worries

Detailed Answer:
Thanks for your response.Since I don't know the cut off value, so I can't say whether yours report falls within the borderline zone .
If your report really falls within the 'borderline' now, then my suggestion is to wait for another 3 months and get repeated all tests including HBsAg . You can consult a Liver specialist with all these reports .
Hope it helps
Regards
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Raju A.T
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Answered by
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Dr. Matin Ahmad Khan

HIV AIDS Specialist

Practicing since :1987

Answered : 298 Questions

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What Does HBSAG Of .99 Indicate?

Brief Answer: These are signal per cutoff (s/c) values Detailed Answer: Hi, Thanks for your question. I am Dr Matin , answering your question. HBsAg is also called Surface Antigen or Australia Antigen. Hepatitis B virus (HBV) tests check for substances in the blood that show whether a hepatitis B infection is active or has occurred in the past. The tests look for different signs of infection (markers) which may be -- antigens, antibodies or the genetic material(DNA) of the virus itself and the genetic material of Hepatitis B is DNA. As antigens are markers made by bacteria or viruses so the presence of HBV antigens means that the virus is in the body and HBsAg is one of the three antigens of HBV found in the blood. Now the results of HBV serologic markers are reported qualitatively or quantitatively as international units (IU) or signal per cutoff (s/c) values. For example, a hepatitis B surface antigen (HBsAg) level of less than 1 s/c may be considered negative, while a level more than 5 s/c is considered positive. Any value between 1 and 5 s/c is indeterminate and should be repeated. So here > 5 s/c value is a cut off value and below this is negative and above this value is a positive result . So your s/c values of two tests (1.08 and 0.99) would have been definitely be lower than a cut off value written in the result report to declare you a negative for Hep B . Moreover there is no standardization between laboratories, and these cutoff values tend to vary between manufacturers. Therefore, results are usually reported as “negative” or “positive.” as per the information from the laboratory or manufacturer’s insert, which is always referenced for quantitative measurement. So I guess your cut off value mentioned in your report must be less than the values you quoted to have declared you as a 'Negative ' for HBsAg. So don't worry, you are not positive . Hope it helps. Keep healthy and be happy. Regards