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What Do These Kidney Function Reports While On BP Medication Indicate?

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Posted on Mon, 24 Oct 2016
Question: Hello, I have a concern about my kidney function. 1.5 years ago I began treatment for high blood pressure, triglycerides, and cholesterol.
Am I likely to have developed moderate kidney disease in 1.5 years or is it more likely to be a result of medication.

My initial blood work showed
Albumin 3.8 g/dL (3.4-5.0)
Calcium 9.0 mg/dL (8.4-10.2)
Carbon Dioxide 30.3 mmol/L (21-32)
Chloride 101 mg/dL (98-107)
Creatinine 0.65 mg/dL (0.4-1.20)
GFR Black 128.4 mL/min
GFR Non-Black 111.1 mL/min
Last week it showed:
Glucose 122 Higher Than Normal mg/dL (70-99)
Urea Nitrogen 27 Higher Than Normal mg/dL (7-18)
Creatinine 1.95 Higher Than Normal mg/dL (.70-1.3)
I have been taking the following for BP and Tri:
Fenofibrate, Nanocrystallized (Tricor Eq.) Tablet 145 mg
Lisinopril/Hydrochlorothiazide (Prinzide Eq.) Tablet 20-12.5 mg
I am very concerned in the move from Normal GFR to Moderate Kidney Disease in a year and a half.
I meant to add my current GFR:
GFR Black 43.4 mL/min
GFR Non-Black 37.6 mL/min

doctor
Answered by Dr. Chobufo Ditah (18 minutes later)
Brief Answer:
For how long did you take Naproxene?

Detailed Answer:
Hi,

Naproxene can cause this reduced kidney function. I will like to know how much and how often you took this drug as well as the total duration. Most interesting, get your kidney function tested 3months later to see where we stand. It is unlikely that this change is real and permanent seen the rapid nature.

Keep me posted on this. I wish you well and feel free to ask for more information and clarifications if need be.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Chobufo Ditah (25 hours later)
Naproxen 500mg twice per day since April 2015. Lisinopril/HCTZ 20/12.5 since March 2016.

I stopped both this week and changed BP meds to NIFEdipine (ADALAT CC) 60mg. Will redo blood test in three weeks. Should I expect an increase in my GFR?
doctor
Answered by Dr. Chobufo Ditah (2 hours later)
Brief Answer:
A definite increase!

Detailed Answer:
Hi,

That was so much Naproxen. With this information, the most likely cause is right there and I believe you will see a much improved GFR following this.

Keep me posted and I wish you well.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Chobufo Ditah (20 hours later)
Thank you for your information. I had expected/hoped my dramatic rise was medicinally induced. My expectation in three weeks is to have my GFR back above 90. Otherwise My family practitioner will refer me to a kidney specialist.
doctor
Answered by Dr. Chobufo Ditah (4 hours later)
Brief Answer:
Share the new values with me!

Detailed Answer:
Hi,

Kindly share the new values after testing with me. I very much look forward to receiving much improved values.

Thanks...
Note: For further queries related to kidney problems and comprehensive renal care, talk to a Nephrologist. Click here to Book a Consultation.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Chobufo Ditah

General & Family Physician

Practicing since :2009

Answered : 6323 Questions

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What Do These Kidney Function Reports While On BP Medication Indicate?

Brief Answer: For how long did you take Naproxene? Detailed Answer: Hi, Naproxene can cause this reduced kidney function. I will like to know how much and how often you took this drug as well as the total duration. Most interesting, get your kidney function tested 3months later to see where we stand. It is unlikely that this change is real and permanent seen the rapid nature. Keep me posted on this. I wish you well and feel free to ask for more information and clarifications if need be.