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What Do My Lab Test Results Indicate?

Posted on Tue, 27 Sep 2016

Question: Hello doctor....As advised we got Jak2 mutation panel and epo level tested. EPO level is 12.6 mIU/mL and V617F mutation in exon 14 of Jak2 gene was NOT DETECTED. exon 12 report is awaited. I have a concern now that if exon 12 comes negative...do we need more tests further?. Also one important point...shall we just discard him as a kidney donor and look for some other family member ?

Answered by Dr. Hardik Sanghvi (1 hour later)

Brief Answer:
Its suggest secondary polycythemia.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.

He has negative jak2 mutation for axon 14 with normal EPO level. If his axon 12 mutation is also negative then it suggest secondary polycythemia.

So further investigation should be done to search the cause of secondary polycythemia.

He can donate the kidney after through investigation. No need to reject the donor just in the basis of secondary polycythemia.

Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer. Thanks for using health care magic. Wish you a very good health.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Hardik Sanghvi (2 hours later)

Thanks doctor !

As per my understanding of polycythemia (through Google) it is a progressive disorder and is a kind of malignancy and organ donation is an absolute Contra -indication in case of haematology malignancy. I hope it is not transferable in case of secondary polycythemia ?

Really worried and confused :((

Answered by Dr. Hardik Sanghvi (1 hour later)

Brief Answer:
Its not malignancy.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.

It is primary polycythemia vera that is malignant proliferative disorder.

Secondary polycythemia is not malignant. It occur secondary to other reasons. So we can not say right now that it is safe or not safe.

First of all we have to search primary cause which leads to secondary polycythemia. If primary cause is not a contraindication for kidney donation then it is ok. He can donate.

Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer. Thanks for using health care magic. Wish you a very good health.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Hardik Sanghvi (13 minutes later)

Thanks doctor. I'll share exon 12 report as and when it comes and will seek your valuable advise to move forward from there....thx

Answered by Dr. Hardik Sanghvi (2 minutes later)

Brief Answer:
You are most welcome.

Detailed Answer:
You are most welcome.
I will wait for your reply.

Thanks for using health care magic.
Wish you a very good health.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Hardik Sanghvi (45 hours later)

Hello doctor,

Good Afternoon !

We met hematologist , he checked the patient clinically and said exon 12 is not required as EPO level is normal?

And said it is secondary polycythemia as there are no symptoms of any sort and he can go ahead with surgery . Wanted to take your opinion on this....thx

Answered by Dr. Hardik Sanghvi (26 minutes later)

Brief Answer:
Yes you can go ahead with surgery.

Detailed Answer:
Hi, dear
I have gone through your question. I can understand your concern.

Yes his epo level us normal so its most likely due to secondary polycythemia.

It is not malignant disease.

If a hematologist examined him and said its OK then he can definitely go for surgery.

As such secondary polycythemia is not contraindication. He can safely donate his kidney.

wish you all the best.

Hope I have answered your all question. If you stillhave any doubts then feel free to ask me any time. I will be happy to answer.

Thanks for using health care magic.
Wish you a very good health.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Hardik Sanghvi (1 hour later)

Thank you very much doctor !

You have been a great support for us ....thanks

Answered by Dr. Hardik Sanghvi (2 hours later)

Brief Answer:
You are most welcome.

Detailed Answer:
You are most welcome.
Thanks for using health care magic.
Wish you a very good health.

Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar