Brief Answer:
I hope i didnt just answer this

Detailed Answer:

There was just another question about calf Pain cannot treat, diagnose or prescribe without being there.
But we can give General information.
pain often gives a lot of clues based on where what type and what triggers it.

where the pain is implies what could be the cause based on what is there.
with calf can be muscle nerve or circulation
can't be gallstones nor heart.
The type of pain can be a clue.

If the type of pain is electric or burning this implies a nerve problem if it is associated with muscle jerking it might be nerve but more likely the muscle if it is with bending it might be a joint problem if it feels tired and sore and hurts with movement it might be not getting enough blood from a circulation problem.

But restless leg is common. Happens at rest or moving and especially middle of the night and feels like a harsh cramp. sometimes fluids and minerals like potassium or magnesium helps. mostly medication is needed.

Other medicine recommendations depends on things I cannot know..
Mostly aspirin like drugs are good but with blood pressure or kidney trouble they could be very dangerous.

Regards

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Brief Answer:
ok, then some points...

Detailed Answer:
more likely the muscle

" if it feels tired and sore and hurts with movement it might be not getting enough blood from a circulation problem".

If an area, especially a large one like both legs, is not getting enough blood, it is likely to require surgery to fix it. It's pretty serious to very serious. There can be a problem with the circulation from atherosclerosis of the large blood vessel from the heart that can break and kill you.

Vascular evaluation by a vascular surgeon. Most hospitals have one.

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Brief Answer:
another approach.

Detailed Answer:
I cannot say in your particular case, not being there.

I've mentioned twice now that if there is a circulatory problem, and it sounds like it, then home remedies is like putting a pill down a clogged pipe to unclog it. IT WON"T WORK; THE PLUMBING NEEDS TO BE UNCLOGGED BY A PROFESSIONAL. As I have said twice without the caps as much.

You don't want to hear what a very likely serious problem might be and how to fix it.

So, instead I will say how to fix minor leg cramps which occur in someone who hasn't built up their leg tolerance. I am not convinced that this applies here.
1) that person would need to build up the muscle tolerance and go with a shorter run more frequent and only gradually with 1/4 to 1/2 mile increases per week build up to longer runs.
2) do some stretching before hand, ideally in the shower because stretching often slightly rips tendons and makes someone more sore.
3) maintain both hydration and enough potassium and magnesium. THe potassium particularly can be lost in exercise.
4) massage afterwards. Maybe an aspirin afterwards, but it is quite dangerous and should only be done under some medical supervision *(there's a risk of stomach irritation)*

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