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What Causes Nodular Sclerosing Hodgkin's Disease?
Question: Can you tell me the typical type of Reed-Sternberg cells that are seen in the most common type of Hodgkin's disease, nodular sclerosing type as far as number of nucleus's seen like double, single or triple nucleus cells?
Brief Answer:
yes.. Reed-Sternberg cells that are seen with multiple lobed nucleus
Detailed Answer:
Hi
Thanks for the query
Nodular sclerosing Hodgkin lymphoma, is the most coomon type.
which constitutes 60-80% of all cases of Hodgkin lymphoma, the morphology shows a nodular pattern. Broad bands of fibrosis divide the node into nodules.
Reed-Sternberg (R-S) cells are nothing but abnormal cells.
Usually people with Hodgkin lymphoma have R-S cells, although other abnormal cell types may be present.
Reed-Sternberg cells continually divide, making more and more abnormal cells, which do not die when they should. As these abnormal cells build up, they can form a mass of tissue called a tumor.
The characteristic cell is the lacunar-type Reed-Sternberg cell, which has a monolobated or multilobated nucleus, a small nucleolus, and abundant pale cytoplasm.
Take care
Regards
Dr Priyanka
yes.. Reed-Sternberg cells that are seen with multiple lobed nucleus
Detailed Answer:
Hi
Thanks for the query
Nodular sclerosing Hodgkin lymphoma, is the most coomon type.
which constitutes 60-80% of all cases of Hodgkin lymphoma, the morphology shows a nodular pattern. Broad bands of fibrosis divide the node into nodules.
Reed-Sternberg (R-S) cells are nothing but abnormal cells.
Usually people with Hodgkin lymphoma have R-S cells, although other abnormal cell types may be present.
Reed-Sternberg cells continually divide, making more and more abnormal cells, which do not die when they should. As these abnormal cells build up, they can form a mass of tissue called a tumor.
The characteristic cell is the lacunar-type Reed-Sternberg cell, which has a monolobated or multilobated nucleus, a small nucleolus, and abundant pale cytoplasm.
Take care
Regards
Dr Priyanka
Above answer was peer-reviewed by :
Dr. Vaishalee Punj
Hello Dr XXXXXXX
Could you tell me if these photos of lymph-node tissue could be consistent with Acute Epstein-Barr Disease? About a year to a year and a half before samples were taken I had symptoms of sore swollen lymph nodes especially in the groin area, fever, malaise, joint aches and an ulcerated raw sore with noticable crusting edge in the groin area and was in bed for a week or two, before it subsided and I was able to function again.
Could you tell me if these photos of lymph-node tissue could be consistent with Acute Epstein-Barr Disease? About a year to a year and a half before samples were taken I had symptoms of sore swollen lymph nodes especially in the groin area, fever, malaise, joint aches and an ulcerated raw sore with noticable crusting edge in the groin area and was in bed for a week or two, before it subsided and I was able to function again.
Brief Answer:
Kindly send the report
Detailed Answer:
Hi
Thanks again
Can you upload the reports? Because slides can be read only by the pathologists.
If you can provide reports with your clinical symptoms, I can correlate clinically and can give the further details.
Take care
Regards
Dr Priyanka
Kindly send the report
Detailed Answer:
Hi
Thanks again
Can you upload the reports? Because slides can be read only by the pathologists.
If you can provide reports with your clinical symptoms, I can correlate clinically and can give the further details.
Take care
Regards
Dr Priyanka
Above answer was peer-reviewed by :
Dr. Yogesh D
Hi, I have provided some attachments. Please review them.
Brief Answer:
Increased alkaline phosphatase level
Detailed Answer:
Hi
Thanks again
I have gone through the attached reports.
The normal range is 44 to 147 IU/L . Normal values may vary slightly from laboratory to laboratory.
But according to the reports there is increase in the alkaline phosphatase value.
This test is performed to determine how well your liver , gallbladder and bone are functioning.
Higher-than-normal ALP levels many of the conditions in with abnormal functioning of liver and gall bladder. Increased levels also seen in Lymphoma and leukemia
Take care
Regards
Dr Priyanka
Increased alkaline phosphatase level
Detailed Answer:
Hi
Thanks again
I have gone through the attached reports.
The normal range is 44 to 147 IU/L . Normal values may vary slightly from laboratory to laboratory.
But according to the reports there is increase in the alkaline phosphatase value.
This test is performed to determine how well your liver , gallbladder and bone are functioning.
Higher-than-normal ALP levels many of the conditions in with abnormal functioning of liver and gall bladder. Increased levels also seen in Lymphoma and leukemia
Take care
Regards
Dr Priyanka
Note: For further queries related to kidney problems Click here.
Above answer was peer-reviewed by :
Dr. Nagamani Ng
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