Question: Since about 8 months, I was suffering from loss of appetite, nausea and some bouts of diarrhea, great anxiety, panic attacks and weight loss (about 20 kilograms). At the beginning, I was treated for about 3 months from IBS. I went to another doctor and during investigations and blood tests I discovered that I have mild hyperthyroidism. He prescribed me Inderal 10 mg for about 1 month. Then after a month the symptoms increased and I was prescribed neomercazole 3 tablets daily, but my condition worsened. The tablets were increased to 6 daily for 6 weeks and a partial improvement was seen in fatigue and sleep after several weeks. I made a blood test on 25/5/2015 (attached) and the doctor told me that this is a strong dose and I neeed to decrease the dose from 6 to 4 pills starting from this date. I made another test after 17 days on 13/6/2015 to check the levels (attached) and the doctor told me to keep the same dose. I noticed that at the end of the second week after decreasing the dose I had some bouts of diarrhea, then symptoms began to worsen again this week which is the third after decreasing the dose. I have some pulsations in my head again, dry mouth, dehydration, more weight loss, can not eat all, can not sleep well, severe anxiety, some shakiness (athough I was still suffering from nausea and anxiety while taking the 6 pills). I am afraid because I won't be able to contact my doctor now and after making the next blood test. I increased the dose from 4 to 5 pills since last Sunday (2 at 6 am, 2 at 2 pm and I increased one at 9 pm) because I feel again that my symptoms are not controlled. I am even afraid that there is a setback as some of the symptoms which had already gone returned and the dose needs further increase despite the normal lab results. Despite increasing the dose by 1 pill since last Sunday, I am still feeling unwell. I heard before that it is ideal to gradually decrease the dose. Was it wrong to cut the dose by 2 pills at once and why did the symptoms worsened after some partial improvement in the last period.

I stopped Inderal because my blood pressure sometimes get low 90/60 and 100/70. What is increasing my anxiety is the feeling of being nauseated even before discovering my hyperthyroidism and the fear of entering into a bout of vomiting and diarrhea and my continuous weight loss. What is worrying me is that I am following with 2 doctors one for my IBS and the other for my thyroid and the doctor f my IBS told me that 6 tablets of neomercazole is a strong dose for me and I should lower to 4 so I did. When I went to my thyroid doctor even after the results were better after 6 weeks he asked me to keep the same dose, then after 2 weeks he asked me to reduce to 5. I already reduced to 4 for a whole month because I was afraid of my colon and to turn hypo and since last Sunday I increased to 5 since my symptoms worsened. So I am perplexed and do not know what to do. People around me advised me to follow the instructions of the thyroid doctor even though the doctor of my IBS is also specialized in other branches as diabetes and endocrinology and he is the one who discovered my hyperthyroidism. Should the dose be lowered after symptoms control or after levels get normal. At the beginning before treatment even after the blood test dated 25/3/2015, symptoms got more worse. When I turn from side to side in bed I could hear my heart pulsations, shakiness, complete fatigue and I could not eat at all so I am afraid to turn to the beginning. I am attaching the earlier tests before treatment.

I am attaching earlier tests before treatment

I made sometests (attached). The dose of neomercazole needs to be reduced and I do not know my doctor will agree or not. What worries me a lot is the cortisol 9 am level. Is this level dangerous. I will not be able to see my doctor until next Friday.

Should the dose be reduced from 5 to 3 because I remained for 4 weeks on 4 tablets and I think these are the results of this month then increased to 5 since last Sunday. I am afraid my doctor won't agree to reduce the dose because he insisted before on 5 tablets eventhough I told him I am afraid of turning hypo. Also I heard that the dose should be gradually reduced, but now I should reduce from 5 to 3. Can this make me hyper again or aggravate my symptoms because the dose should be gradually reduced. I am not fasting because I am taking the medication every 8 hours , but I am afraid of the cortisol test result especially that it was 4.7 (4.3-22.4) on 13- 6 - 2015 then dropped to 3.6 yesterday in the same month.