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What Causes Increase In Lipase And Amylase Levels?

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Posted on Wed, 2 Dec 2015
Question: Hi Doctor, I am 58 year old female, who last year had normal lipase and amylase levels of 300, had an endoscope ultrasound and CT scan to rule out pancreatic disease. Nothing abnormal, been taking enzymes 5000 for about 6 months, now my levels are over 600!! I am not an alcoholic! No doctor has suggested lung or ovarian cancer. Had DCIS with radiation in 2008. Not sure what to do next! Please help. Thank you
doctor
Answered by Dr. Abhijit Deshmukh (9 hours later)
Brief Answer:
hi

Detailed Answer:
Hello
Welcome to HCM
Thank you for the query
I understand your concern
Well if you never had pain during the episodes of rise of lipase and amylase then likely it is not related to pancreas.
Also need to know the exact reports and the normal range of that particular laboratory where the test was carried out.
Also is your creatinine normal otherwise it's common to have raised levels in kidney disease also.
Some drugs can cause rise in levels but does not look like you are on one.
Can get serum macroamylase levels checked if available in your country which is a normal conditions where amylase is not excreted by kidney and thus have raised blood levels of same.
All in all looks like not much to worry
Hope this answers your query
Best wishes
Happy to help
Above answer was peer-reviewed by : Dr. Sonia Raina
doctor
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Follow up: Dr. Abhijit Deshmukh (11 hours later)
So let me confirm, I should ask my doctor if my creatinine levels have been checked? That Amylase can be raised in kidney disease too! Also ask my doctor for a serum macroamylase test? I presume this is all done in the blood work?

Doctor just to remind you my lipase levels are normal, I will try to get a copy of my blood work, to let you know the normal lab levels.

I have had one episode of pain a year ago, this is when I had blood level amylase of 300! Had an CT scan and endoscope ultrasound showing no disease but a narrow bile duct! thats it! Doctor ordered the 5000 mg Amylase enzymes with each meal!

Could these enzymes be the causing the rise in Amylase? Thank you for your responses.

DJ
doctor
Answered by Dr. Abhijit Deshmukh (13 hours later)
Brief Answer:
hi

Detailed Answer:
Hello
Yes get your creatinine check if not done earlier.
If you had pain a year back then likely the source is pancreatic only, then no point in checking macroamylase levels.
Send me all your reports.
Best wishes
Note: For further follow up on digestive issues share your reports here and Click here.

Above answer was peer-reviewed by : Dr. Prasad
doctor
Answered by
Dr.
Dr. Abhijit Deshmukh

Gastroenterologist

Practicing since :2001

Answered : 597 Questions

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What Causes Increase In Lipase And Amylase Levels?

Brief Answer: hi Detailed Answer: Hello Welcome to HCM Thank you for the query I understand your concern Well if you never had pain during the episodes of rise of lipase and amylase then likely it is not related to pancreas. Also need to know the exact reports and the normal range of that particular laboratory where the test was carried out. Also is your creatinine normal otherwise it's common to have raised levels in kidney disease also. Some drugs can cause rise in levels but does not look like you are on one. Can get serum macroamylase levels checked if available in your country which is a normal conditions where amylase is not excreted by kidney and thus have raised blood levels of same. All in all looks like not much to worry Hope this answers your query Best wishes Happy to help