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What causes elevated Gamma GT?

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Internal Medicine Specialist
Practicing since : 2009
Answered : 2746 Questions
Doctor, I am suffering from jaundice (though I did not have any symptoms). In the ultrasound taken on 02 XXXXXXX it is learnt that. I have cholelithiasis(4-5 calculi seen in GB) (Status Post Hysterectomy).. LFT taken after 12 days of treatment shows that I have an increase Gamma GT (332) SGOT (213) SGPT (275) Total BILRUBIN (0.8 - DIRECT 0.4), (First report on02 XXXXXXX it was 3.6) ALKALINE PHOSPHATE (207 - THIS WAS NORMAL IN THE FIRST REPORT (116))Gamma GT. It is learnt that elevated Gamma GT is due to alcohol consumption, whereas I have never taken drinks even once in my life. Then what is the cause for it Doctor?
Posted Mon, 3 Feb 2014 in Liver and Gall Bladder
Answered by Dr. Anshul Varshney 27 minutes later
Brief Answer: Gamma GT can be raised in Biliary tract disease Detailed Answer: Dear XXXX Welcome to XXXXXXX I am Dr Anshul Varshney, I will try to help you by answering your query. Your LFT is suggestive biliary tract disease. And the cause we have , that is cholelithiasis. You have learnt that Gamma GT is raised in alcholics and alcoholic liver disease. But you need to know that it is also increased in Biliary tract diseases. Also commonly it is increased with use of a few drugs like barbiturates , phenytoin. So you need not to worry for Gamma GT elevation. That is part of biliary tract disease. I would advise you take proper treatment for your biliary tract disease. Once it is treated everything will come to normal in some time. This is my best opinion based on details available. You should discuss with your doctor about my opinion , I am sure he / she would agree to this. If you have any further query , you may ask me.
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Follow-up: What causes elevated Gamma GT? 4 hours later
Dear Doctor, Thank you for answering my question. But, I have missed out some more points. I felt some tightness around the area below the shoulders for thrice (twice before I went for check up and once during the treatment). Initially I got alright after resting for a while. Second and third time I vomited & with the vomiting I felt alright. After the initial discomfort, next morning, urine was dark yellow and second time it was red. This was the reason I consulted a Doctor and jaundice was confirmed in the blood and urine tests done. I also underwent tests for Hepatitis B and C (tested negative) and ultrasound of the whole abdomen Now, Doctor, I just wanted to know whether it is related to jaundice or bilary duct problems. If it is due to bilary duct problems, then should I continue the treatment which I am taking now? I had been taking calcium tablets (Bio-D Strong) regularly after my wrist fracture and both calcium (Gemcal D3) and Menopace tablets after hysterectomy. Also for the past few months I had been taking homoeopathic treatment for pigmentation. I stopped taking these medicines since the diagnosis of jaundice, though Doctor advised me to continue those medicines (calcium and menopace). Further, I would like to inform you that I am not in the habit of taking water. But I take 3-4 cups of tea daily, sometimes even more. Whether this also has anything to do with my problems. (All my Test Results are given in the page below). Thanking you, Yours Sincerely, Jancy XXXXXXX (A) TEST REPORT ON 02 XXXXXXX 14 (TEST FOR JAUNDICE) URINE EXAMINATION : TESTED POSITIVE FOR BILE PIGMENTS AND BILE SALTS BIOCHEMISTRY : Total Bilrubin – 3.6 mg/dl Direct Bilrubin – 1.9mg/dl Indirect - 1.7 mg/dl SGOT/AST – 513 U/L SGPT/ALT – 574 U/L Alkaline Phosphate – 116 U/L (B) ULTRASOUND OF WHOLE ABDOMEN REPORT ON 04 XXXXXXX 14 Liver is normal in size and shows normal echopattern No focal lesions seen in liver. IHBR are not dilated. Gall Bladder is well distended. Few 4-5mm calculi seen in GB. GB wall is not thickened. Portal vein & CBD are normal in calibre (CBD measures 4mmat porta) Pancreas shows normal echotexture and contopur Spleen is normal in size. No focal lesion seen in spleen Both kidneys are normal in size and echopattern No hydronephrosis or calculus seen on either side No retroperitoneal lymphadenopathy seen No pleural effusion seen on either side. No ascites seen Bladder is full and shows echofree contents Uterus is not visualised. No pelvic mass seen. (C) REPORT OF LFT ON 15 XXXXXXX 14 Total Bilrubin : 0.8mg/dl Direct Bilrubin : 0.4 mg/dl SGOT/AST : 213 U/L SGPT/ALT : 275 U/L Alkaline Phosphate : 207 U/L GGT : 332 U/L Total Protein : 7.3 gm/dl Albumin : 4.5 gm/dl Globulin : 2.8gm/dl A/G Ratio : 1.6
Answered by Dr. Anshul Varshney 3 hours later
Brief Answer: Detail Follows. Detailed Answer: Dear XXXX I have read your problem and reviewed your reports. The symptoms you are describing were due to jaundice only. But trust me , your initial levels of ALT/AST were very high , you should have got admitted. However , luckily you did not get any complications. The medicines you are taking won't help your liver and biliary system , in fact as such no medicine will cure your disease. I feel you might have Acute Viral Hepatitis. Hepatitis A and E can be there if B and C are negative. I advise you to get following investigations 1. Anti HAV Antibody 2. Anti HEV Antibody. If they come out to be negative , we will attribute your jaundice to cholelithiasis , that is biliary tract disease and you would require cholecystectomy with exploration of common bile duct as soon as possible. I hope i am able to solve your query , ask me if you have any further query , if not , you may please close the discussion and rate it. Good Luck.
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