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What Causes Chills, Fatigue And Weight Gain Despite Taking Thyronorm For Hypothyroidism?

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Posted on Wed, 19 Aug 2015
Question: Hello Doctor,
I am a 39 year old female. I was diagnosed with Hypothyroidism and PCOD in 2008. I was suffering from the usual Hypothyroidism symptoms like chill, fatigue, hairfall, weight gain of 20 kgs almost overnight and puffiness of face. Also, infertility as I had not conceived till then, almost 8 years into my marriage. My family friend (Doctor) suspected Hypothyroidism and asked me to take a thyroid blood test which confirmed that I was suffering from Hypothyroidism. I was advised Thyronorm 100 mg 6 days a week. After the medication my symptoms somewhat gradually subsided and I started feeling normal again. My Doctor advised me to take the T4 and TSH tests every 3 months to see if my medicine was working fine. I used to take the test and my medicine regularly. My medication used to be adjusted as the blood work showed some fluctuation in T4 and TSH values or if there was some symptoms like not getting lung full of air. Sometimes the medication would be adjusted to 150 Mg and 100 mg on alternate days basis my values of T4 and TSH and breathing symptoms. If there was some breathing problem my medication would be reduced to 100mg per day. Things were fine and gradually I also got complacent and started to neglect the 3 monthly blood test and visit to the Doctor though I continued with my medication i.e. 100 mg 6 days a week. I would take the test randomly at 6 months or a year and the values would appear normal (Read between the range) and I would continue with the 100 mg medication.
In the meantime, I conceived twice once in 2009 and again in 2010, for the first time, but both pregnancies resulted in miscarriage. They were termed as Pregnancies of Unknown Location by the doctors at Fortis, and I was treated with Methotrexate. Post 2010, I have not tried at all, since I was very depressed and the entire experience in 2009-10 was emotionally and financially draining too.
Off late for the last 2 years my hair fall has become severe, so much so that I think I will get bald in few years. Also I am getting frequent and severe throat infections (3 to 4 times in last 2 years). Everytime, my voice becomes hoarse like you have during laryngitis. I consulted a physician, an ENT specialist and a chest specialist. They ran a battery of tests like chest x-ray, pulmonary function test, blood tests. Everything came normal except hemoglobin and hematocrit which were low and RDW which was high (I have read that elevated RDW is symptom of iron deficiency). They concluded that it is allergy/chronic sinus and have asked me to take steam inhalation twice a day to unclog the sinuses. Temporarily I was also advised steroids early last year, and I was off it after 2 months post the symptoms of wheezing subsided. The throat infections still continue every 2-3 months.
I recently took an Iron profile test along with complete thyroid profile on my own. I am attaching this report along with the last two thyroid tests which I had taken in Aug 2014 and XXXXXXX 2015 for your reference. All these blood tests were taken on empty stomach first thing in the morning.
My last 3 tests appeared normal to me, (I know that I am not a Doctor but I am basing my observation basis the values within range) but I would like to have an expert opinion on this as I have realized that these values(T3,T4,TSH) are relative to each other and only an expert can understand the report. I am particularly worried by my Iron profile test where the Transferrin Saturation level is 14.5% even though other values appear to be in range. Please advise me if
1.     I am suffering from anemia.
2.     Does my Thyroid medication needs to be adjusted? (Currently I am taking 100 mg of Thyronorm 6 days a week).
3.     Also please advise me if the thyroid medication I am taking is getting converted into T3. My T4 value is on the higher side whereas T3 is on the lower side.
4.     If T4 is not adequately getting converted to T3, would you recommend T3 medication like liothyronine provided it is available in XXXXXXX
5.     I would like to increase my Ferritin level. Currently it is on the lower side 24.40 ng/ml (Range 10-120).
Warm Regards XXXXXXX
doctor
Answered by Dr. Ajish TP (2 hours later)
Brief Answer:
Thyroid dose can be increased, take iron tablets

Detailed Answer:
Hi Mrs XXXXXXX

Welcome to HCM. I have gone through the question and understand your concerns.

You are having hypothyroidism and mild iron deficiency anemia. The answers to your questions:

1. You are having mild anemia. Iron, ferritin, hemoglobin are on lower side, transferrin low and TIBC higher side.

You can start on iron supplementation and retest after 3-6 months.

2. Thyroid function is almost normal. But since you had 2 miscarriages, it is always better to keep the TSH below 2.5. So I suggest you to take thyroid medications 100 mcg daily morning empty stomach instead of 6 days a week. Please be regular with mediations.

Additional investigations like anti TPO antibodies and ultrasound thyroid can help you in understanding the type of hypothyroidism and need for life long treatment.

When you get pregnant the thyroxine dose has to be increased by 20-30% ( that is to 125 mcg). This is because the requirements increase in pregnancy. Not increasing the dose can be a reason for miscarriages.

3. Your thyroid medication is getting converted to T3. Your T3 and free T3 are on normal range. The thyroid medications available in XXXXXXX are all T4 preparations. So while on treatment T4 will be on higher side of normal and T3 on lower side of normal.

4. To the best of my knowledge we don't have T3 medications in XXXXXXX It is available abroad as Cytomel 5 mg tablets. Always T3-T4 combination treatment is better.

5. You can increase the ferritin by adding iron supplements.

Hope I have answered your questions. If you have any further queries I will be happy to help you

Regards,

Dr Ajish TP [MD,DM]
Consultant Endocrinologist
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Ajish TP (46 hours later)
Thank you Doctor for your prompt response. As suggested by you I am going to increase my Thyroid medication to 7 days a week. You have suggested that I have mild anemia and I need to be on iron supplements. Can you please prescribe me a good iron supplement and how much micrograms should I be taking in order to raise my low levels. I have read that the iron supplements are available in various forms such as Ferrous Sulfate, Ferrous Glutamate, Ferrous Fumerate, Ferrous Bisglycinate, etc. I would request you to prescribe me a form which does not give constipation.

I have also read about that iron supplements come in two forms i.e heme and nonheme, and that heme form of iron is the best absorbable form of iron. Will you prescribe me heme form of iron supplement? If so, preferably in liquid form so that I can mix it with orange juice for better absorption. Please let me know the gap between the intake time of Thyroid medication and iron supplement to avoid miss absorption of thyroid medicine.

Guess you missed my question around the severity of hair fall, is there anything I can do to control it as its the most visible form of ailment at the moment and most disturbing too :)

Thanks and warm regards XXXXXXX
doctor
Answered by Dr. Ajish TP (22 hours later)
Brief Answer:
See detailed answer

Detailed Answer:
Hi,

Welcime back.
Answers to your questions:

1. All iron preparations are associated with constipation and gastritis. If you need to choose an iron preparation with less gastric side effects , I suggest you syrup Aloha, which contain carbonyl iron. Dose is 10-15 ml per day. You require 100-150 mg per day.

Other preparations like Hemsi, Hemeup, Dexorange etc can be tried. If you develop any side effect the dose can be reduced. Most of these medications are well tolerated at lower dose. In your case the deficiency is mild so you can take lower dose.

2. The gap between thyroxine and iron is at least 1 hour.

3. Hair fall - is a difficult thing to treat. We try to treat causes like vitamin deficiencies, hypothyroidism, dandruff, stress, other hormone disorders like PCOS etc. But most of the hair loss is without a definite identifiable cause.

Regards
Dr Ajish TP
Note: For more information on hormonal imbalance symptoms or unmanaged diabetes with other comorbid conditions, get back to us & Consult with an Endocrinologist. Click here to book an appointment.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Ajish TP

Endocrinologist

Practicing since :2002

Answered : 819 Questions

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What Causes Chills, Fatigue And Weight Gain Despite Taking Thyronorm For Hypothyroidism?

Brief Answer: Thyroid dose can be increased, take iron tablets Detailed Answer: Hi Mrs XXXXXXX Welcome to HCM. I have gone through the question and understand your concerns. You are having hypothyroidism and mild iron deficiency anemia. The answers to your questions: 1. You are having mild anemia. Iron, ferritin, hemoglobin are on lower side, transferrin low and TIBC higher side. You can start on iron supplementation and retest after 3-6 months. 2. Thyroid function is almost normal. But since you had 2 miscarriages, it is always better to keep the TSH below 2.5. So I suggest you to take thyroid medications 100 mcg daily morning empty stomach instead of 6 days a week. Please be regular with mediations. Additional investigations like anti TPO antibodies and ultrasound thyroid can help you in understanding the type of hypothyroidism and need for life long treatment. When you get pregnant the thyroxine dose has to be increased by 20-30% ( that is to 125 mcg). This is because the requirements increase in pregnancy. Not increasing the dose can be a reason for miscarriages. 3. Your thyroid medication is getting converted to T3. Your T3 and free T3 are on normal range. The thyroid medications available in XXXXXXX are all T4 preparations. So while on treatment T4 will be on higher side of normal and T3 on lower side of normal. 4. To the best of my knowledge we don't have T3 medications in XXXXXXX It is available abroad as Cytomel 5 mg tablets. Always T3-T4 combination treatment is better. 5. You can increase the ferritin by adding iron supplements. Hope I have answered your questions. If you have any further queries I will be happy to help you Regards, Dr Ajish TP [MD,DM] Consultant Endocrinologist