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What Are The Uses And Effects Of Sertindole?
Question: Hi,
As far as i understand, it takes 12 days to sertindole to reach steady plasma concentrations, but this doesn't means that the med has its full effect. I would like to know if sertindole has a strong cumulative effect and then i can expect important positive new effects after 12 days (i am at 8 mg).
Thanks XXXXXXX
As far as i understand, it takes 12 days to sertindole to reach steady plasma concentrations, but this doesn't means that the med has its full effect. I would like to know if sertindole has a strong cumulative effect and then i can expect important positive new effects after 12 days (i am at 8 mg).
Thanks XXXXXXX
Brief Answer:
Private Consultation
Detailed Answer:
Hello XXXXXXX and thanks so much for reaching out to me directly.
Sertindole acts primarily at two receptors, dopamine and serotonin receptors, in the brain. You are correct that it typically takes around 12 days to reach steady plasma concentrations. The first effects seen are typically dopaminergic effects -- decreasing hallucinations, delusions, and causing sedation. These effects can be seen in a matter of hours or days. The serotonin effects, primarily antidepressant effects, take longer to reach full efficacy -- typically 2-4 weeks after the medication reaches steady plasma concentrations. So to answer your question directly, yes -- you should see continued increase in benefits over the next 2 to 4 weeks.
Dr. Sheppe
Private Consultation
Detailed Answer:
Hello XXXXXXX and thanks so much for reaching out to me directly.
Sertindole acts primarily at two receptors, dopamine and serotonin receptors, in the brain. You are correct that it typically takes around 12 days to reach steady plasma concentrations. The first effects seen are typically dopaminergic effects -- decreasing hallucinations, delusions, and causing sedation. These effects can be seen in a matter of hours or days. The serotonin effects, primarily antidepressant effects, take longer to reach full efficacy -- typically 2-4 weeks after the medication reaches steady plasma concentrations. So to answer your question directly, yes -- you should see continued increase in benefits over the next 2 to 4 weeks.
Dr. Sheppe
Above answer was peer-reviewed by :
Dr. Prasad
Hi,
Thanks for your answer. I am interested in dopminergic effects, not in antidepressant ones, so i would like to know if i can expect more of these effects in the following weeks, i mean, up to the full dopaminergic effects. XXXXXXX
Thanks for your answer. I am interested in dopminergic effects, not in antidepressant ones, so i would like to know if i can expect more of these effects in the following weeks, i mean, up to the full dopaminergic effects. XXXXXXX
Brief Answer:
Private Followup
Detailed Answer:
Thanks for the clarification.
Yes -- while the dopaminergic effects START sooner than the serotonergic effects, they similarly take 4-6 weeks to reach FULL effect. I would monitor your symptoms over the next 4-6 weeks for continuing improvement. I would expect improvement as the body adjusts to the drug and dopaminergic changes continue to occur.
Dr. Sheppe
Private Followup
Detailed Answer:
Thanks for the clarification.
Yes -- while the dopaminergic effects START sooner than the serotonergic effects, they similarly take 4-6 weeks to reach FULL effect. I would monitor your symptoms over the next 4-6 weeks for continuing improvement. I would expect improvement as the body adjusts to the drug and dopaminergic changes continue to occur.
Dr. Sheppe
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Above answer was peer-reviewed by :
Dr. Raju A.T
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