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What Are The Side Effects Of Toprol XL And Supermet XL?

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Posted on Mon, 6 Apr 2015
Question: Hi, I have taken Toprol XL, 50 mg for about 15 years. Along with Lotrel 5/20 mg my blood pressure has been controlled very well. Recently the company that fills my metoprolol changed pharmacies and they gave me Supermet XL, 50 mg. About the same time (mid December, 2014) I was prescribed Wellbutrin, 150 mg once daily for a mild depression I could not seem to shake off. It seemed to be helping with no apparent side effects and I was pleased...until at 1:30 a.m. one night in mid January, 2015 I was surprised to see a car drive up in my driveway and out came 6-8 men dressed in green and white striped prison suits and began working on a fence row between my house and my neighbors. I've worked nights in the past and I'm usually awake...I opened the door, asked the men what they were doing. They looked at me but did not speak. I tried my best, but they just weren't in the mood to talk. Couple of nights later, the children of the corn showed up...same thing...just looked at me, wouldn't talk. Next night I woke up, my ex husband was standing by my bed holding up a jar of Nutella. I asked him what he was doing. He set the jar down and left quietly...no talking. Next morning I stopped taking the Wellbutrin...no more night visitors or hallucinations. Until Supermet XL. After about 2 weeks I became convinced my oldest daughter and her husband were planning on having me nonvoluntarily committed to a mental hospital. After being told many times they were not, I decided to ignore people who I thought were calling from local hospital mental departments to tell me they were coming after me (no one sang "ha ha, ho ho, hee
hee"). After I began ignoring these calls, the delusions began to lessen. I have noticed however, that during the night I wake up to one or two calls...less severe, but still troubling. I think this might provide your Thursday night with a little humorous sidetrip. Actually, I think it's pretty hilarious, too...that is, unless it's not medication side effects. I had always taken AstraZeneca metoprolol. Do you think this side effect could be partially caused by the confusion and hallucinations that Supermet XL may cause and could be possibly exacerbated by the recent wellbutrin episodes? I am a 66 year young woman in good health otherwise. I'm countin' on you, Doc to tell me "yep, that's it" and "no way is this a shining example of early senility". I apologize for the length, but hope it brings a smile to you and your colleagues faces.
doctor
Answered by Dr. Seikhoo Bishnoi (5 hours later)
Brief Answer:
Supermet XL is the probable reason for symptoms

Detailed Answer:
Hello, Welcome to Health Care Magic

I can understand your concern. You were taking Toprol XL 50 and then started on Supermet XL 50. Both drugs are same and consists of Metoprolol. Metoprolol is a beta blocker drug. The drug is a lipophillic drug and can cross blood barrier to reach brain. There are numerous case reports available which found that Metoprolol can cause CNS side effects and can result in visual hallucinations and some times abnormal belief. Though you were taking Toprol and didn't develop such symptoms and then developed with Supermet. This probably happened because of different manufacturing processes involved in making the drugs and slight differences in pharmacodynamics can occur between two drugs of different makers. Also Wellbutrin or Bupropion is known to cause or aggravate hallucinations, and the drugs increased risk of hallucinations. I don't think this is related to any psychotic process or any senile changes, thought if symptoms persist then evaluation is warranted.

If beta blockers are needed for your BP control then you can ask your doctor to shift you to some hydrophillic beta blockers like Atenolol, which don't cause Central nervous system (CNS) side effects. This would reduce these side effects.

Thanks, hope this helps, please ask again if you have more doubts.


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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5193 Questions

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What Are The Side Effects Of Toprol XL And Supermet XL?

Brief Answer: Supermet XL is the probable reason for symptoms Detailed Answer: Hello, Welcome to Health Care Magic I can understand your concern. You were taking Toprol XL 50 and then started on Supermet XL 50. Both drugs are same and consists of Metoprolol. Metoprolol is a beta blocker drug. The drug is a lipophillic drug and can cross blood barrier to reach brain. There are numerous case reports available which found that Metoprolol can cause CNS side effects and can result in visual hallucinations and some times abnormal belief. Though you were taking Toprol and didn't develop such symptoms and then developed with Supermet. This probably happened because of different manufacturing processes involved in making the drugs and slight differences in pharmacodynamics can occur between two drugs of different makers. Also Wellbutrin or Bupropion is known to cause or aggravate hallucinations, and the drugs increased risk of hallucinations. I don't think this is related to any psychotic process or any senile changes, thought if symptoms persist then evaluation is warranted. If beta blockers are needed for your BP control then you can ask your doctor to shift you to some hydrophillic beta blockers like Atenolol, which don't cause Central nervous system (CNS) side effects. This would reduce these side effects. Thanks, hope this helps, please ask again if you have more doubts.