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What Are The Side Effects Of Solian?
Question: Hi
I've started Solian-Amisulpride 50 mg instead of Solian 100mg, i am on Lexapro 15 mg, Keppra 1000 mg and Klonopin 5 mg. I've been told that it's possible to be on Solian 50 mg for a while and then go back to Solian 100 mg. Dose was lowered because i have anxiety and a "fixation" with dopaminergic effects of Solian 100 mg.
I would like to know if while i am on Solian 50 mg and as far as i understand there is less dopaminergic activity and also less activity on 5ht7 (i was told that also 5ht2b was involved), then these receptors are vacant and can be occupied by the action of Lexapro in serotonin receptors and perhaps also by control of Klonopin on catecholamines and maybe also Keppra's action. Thus, this new "occupation" would beat the competition against Solian and i could return later to 100 mg with symptoms of obsessive fixation left behind and that are already now minimal. I do not know if I'm understanding the process but something similar let me solve the problem in 2009, as far as i understand (even if i was then taking some Serlect for three weeks in minimal dose and i was on Lexapro 10 mg, instead of 15 mg now). What i mean is that with Solian 50 mg there will maybe be some "vacant" in receptors and another way of action of my meds which could "correct" my lasting "fixation" and then allow to go back to 100 mg.
Thanks beforehand XXXXXXX
I've started Solian-Amisulpride 50 mg instead of Solian 100mg, i am on Lexapro 15 mg, Keppra 1000 mg and Klonopin 5 mg. I've been told that it's possible to be on Solian 50 mg for a while and then go back to Solian 100 mg. Dose was lowered because i have anxiety and a "fixation" with dopaminergic effects of Solian 100 mg.
I would like to know if while i am on Solian 50 mg and as far as i understand there is less dopaminergic activity and also less activity on 5ht7 (i was told that also 5ht2b was involved), then these receptors are vacant and can be occupied by the action of Lexapro in serotonin receptors and perhaps also by control of Klonopin on catecholamines and maybe also Keppra's action. Thus, this new "occupation" would beat the competition against Solian and i could return later to 100 mg with symptoms of obsessive fixation left behind and that are already now minimal. I do not know if I'm understanding the process but something similar let me solve the problem in 2009, as far as i understand (even if i was then taking some Serlect for three weeks in minimal dose and i was on Lexapro 10 mg, instead of 15 mg now). What i mean is that with Solian 50 mg there will maybe be some "vacant" in receptors and another way of action of my meds which could "correct" my lasting "fixation" and then allow to go back to 100 mg.
Thanks beforehand XXXXXXX
Brief Answer:
Consultation
Detailed Answer:
Hello again XXXXXXX and thank you very much for your question.
You've proposed an interesting mechanism of action here. You describe the Solian decrease resulting in unoccupied serotonin receptors. You wonder if Lexapro could occupy these receptors, and thereby prevent Solian from binding to those receptors if and when it is eventually increased to 100mg.
This is not exactly how this works, and let me explain why. First, when a receptor is activated, it does not matter what is activating it -- whether that be Solian or Lexapro -- the receptor is still activated and the effects of that receptor are seen. So really, if you think about it, the idea about Lexapro replacing Solian as actors at serotonin receptors does not play out, because either way those receptors will be activated and the effects will be seen.
Let me go a step further. When receptors are occupied by a molecule such as Lexapro, this binding does not occur in a permanent way such that the receptor is "blocked" for other molecules such as Solian to bind. Solian and Lexapro will both bind to these receptors in dynamic ways, without preference for one or the other. So Lexapro cannot block Solian like this per se.
What I suspect is actually happening here is this. Solian has complicated effects at many receptors -- D2, D3, 5HT7, 5HT2b -- and the delicate balance of actions at these receptors is what will determine the clinical picture. Your doctor wants to try 50mg and see what the mixture looks like clinically for you -- I think in your case this is a good idea. Let's see what this new mix brings.
I hope this was helpful to you.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Consultation
Detailed Answer:
Hello again XXXXXXX and thank you very much for your question.
You've proposed an interesting mechanism of action here. You describe the Solian decrease resulting in unoccupied serotonin receptors. You wonder if Lexapro could occupy these receptors, and thereby prevent Solian from binding to those receptors if and when it is eventually increased to 100mg.
This is not exactly how this works, and let me explain why. First, when a receptor is activated, it does not matter what is activating it -- whether that be Solian or Lexapro -- the receptor is still activated and the effects of that receptor are seen. So really, if you think about it, the idea about Lexapro replacing Solian as actors at serotonin receptors does not play out, because either way those receptors will be activated and the effects will be seen.
Let me go a step further. When receptors are occupied by a molecule such as Lexapro, this binding does not occur in a permanent way such that the receptor is "blocked" for other molecules such as Solian to bind. Solian and Lexapro will both bind to these receptors in dynamic ways, without preference for one or the other. So Lexapro cannot block Solian like this per se.
What I suspect is actually happening here is this. Solian has complicated effects at many receptors -- D2, D3, 5HT7, 5HT2b -- and the delicate balance of actions at these receptors is what will determine the clinical picture. Your doctor wants to try 50mg and see what the mixture looks like clinically for you -- I think in your case this is a good idea. Let's see what this new mix brings.
I hope this was helpful to you.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Above answer was peer-reviewed by :
Dr. Raju A.T
Dear Dr. Sheppe,
Thanks a lot for your answer, i understand. My question obeys to this: in 2009 i was without Solian 4 weeks then back to 100 mg and my problem disappeared, it's true that at the same time Lamictal was replaced by Keppra. After some time with Solian 50 mg it will be possible to go back to Solian 100 mg without bad symptoms, if the clinical picture is better?
Dr. Sheppe,
I forgot...I would like to know also if Solian has a cumulative effect.
Thanks, XXXXXXX
Thanks and regards, XXXXXXX
Thanks a lot for your answer, i understand. My question obeys to this: in 2009 i was without Solian 4 weeks then back to 100 mg and my problem disappeared, it's true that at the same time Lamictal was replaced by Keppra. After some time with Solian 50 mg it will be possible to go back to Solian 100 mg without bad symptoms, if the clinical picture is better?
Dr. Sheppe,
I forgot...I would like to know also if Solian has a cumulative effect.
Thanks, XXXXXXX
Thanks and regards, XXXXXXX
Brief Answer:
Follow-up
Detailed Answer:
I understand your follow-up question. The answer is yes -- Solan can be increased to 100mg without bad side effects if the clinical picture improves. The effect is not cumulative, but rather is only active at the current level/dose -- in other words, past exposure to Solian does not add in effect to your current dose's effects, only the current dose matters.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Follow-up
Detailed Answer:
I understand your follow-up question. The answer is yes -- Solan can be increased to 100mg without bad side effects if the clinical picture improves. The effect is not cumulative, but rather is only active at the current level/dose -- in other words, past exposure to Solian does not add in effect to your current dose's effects, only the current dose matters.
Dr. Sheppe
tinyurl.com/DrSheppeAnswers
Note: For further follow up on related General & Family Physician Click here.
Above answer was peer-reviewed by :
Dr. Prasad
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