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What are the effect of low dose testosterone on eye?

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Subject: Effect of low dose testosterone on eye. Are the effects on the cornea/ lens cells embedded permanently there or temporary until higher endigenous testosterone exposure?
Posted Sat, 17 Nov 2012 in Vision and Eye Disorders
 
 
Answered by Dr. Kulbir Singh 10 hours later
Hello and thanks for the query
Testosterone therapy may produce side effects that aren't serious and may fade with time. But if your symptoms increases with continuous use of drug than you have to immediately stop the drug and consult your treating doctor for this.

Blurry vision or temporary blindness is one of the side effect of this medicine, it recovers by discontinuing the medicine. If you have other related symptoms like weakness, dizziness, pain throughout the body, acne, tingling or burning sensations in the skin, insomnia, lowered libido, light-headedness, than you have to immediately discontinue the medicine. We have no other option left.

Please feel free to consult your treating doctor, so that he can make a decision whether drug should be continued or not depending upon the symptoms you have.

Hope I have answered your query. Write back if you have other related queries.
Best Wishes and have a good time.
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 5 hours later
Dear Dr XXXXXXX

Thank you for your advice. I actually took a short course of low dose oxandrolone.

I understand from your advice that side effects such as blurred vision recovers after discontinuation. Forgive me for asking , does this mean the cells in the eye recover to a state same as pre low dose testosterone/androgen use?

Pardon me for this, but i'm interested in whats going on at the cellular level.


I understand that cells in eye lens for example cannot regenerate themselves. But what about the androgen receptors within, do they get regenerated? Or become degraded and then new receptors generated?? I assume they must as how does future interaction with circulating androgens occur?


Your opinion would be appreciated. thanks in advance

XXXXXXX
 
 
Answered by Dr. Kulbir Singh 1 hour later
Hello and again thanks for the follow up query
Happy to know you that you want to know the mechanism of action of the medicine. It is difficult to understand if you are not from medical line. I will try my best to make you understand.
The effects of testosterone in humans occur by way of two main mechanisms: by activation of the androgen receptor and by conversion to estradiol. Free testosterone is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor by the cytoplasmic enzyme. The receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the DNA. In the eye, cases of retinal thrombosis (clotting), spasms and detachment have been reported that is causing Blurred vision. And when the drug is stopped the activated receptors came back to normal and result in normal vision. Although it can take some time to recover.

Hope you got your answer for the query. Write again if you have another query. I will be glad to answer it.
Best Wishes and have a healthy life.
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 6 hours later
Thank you for your advice Dr XXXXXXX

Thats correct i am from Business background but my mum is chemistry teacher hence the interest in science . i took 6 months oxandrolone when i was younger .I have some more queries if i may....


I understand, from reading books, that eye and brain organs are the only ones whose cells do not regenerate. But what about cell contents ie androgen receptor, is it possible these regenerate or even die and new ones formed?


Also, i want to ask about DNA after encountering these activated receptors...Is there any lasting effect on the DNA sequence site for this brief encounter with the activated receptors ?



Your advice would be greatly appreciated Dr XXXXXXX

Best Regards,
XXXXXXX
 
 
Answered by Dr. Kulbir Singh 50 minutes later
Hello XXXXXXX and again thanks for the query
Firstly I want to know, why you want to know about the cell regenerate or dies or formed? It has nothing to do with your problem and even for treatment.
Every cell has its own life span and it is the natural process of the body that old cell dies and new formed and the cycle goes on. Androgen receptor binding take place in cell and it dies when cell dies. New binding takes place in new cell which is already formed. The cycle goes on till the person is alive.
As per DNA sequence is concern it cannot be changed by any means. DNA sequence is always same for a specific person and is same even after death. DNA only plays a role of a carrier.

It is a long story and needs a complete chapter to understand. You can search it on net or read it on books that how the cell is formed and dies and what role does DNA plays in the body.

Hope you understand or try to understand the mechanism of the body. Write again if you have other query related to health.
Best Wishes and have a real good time.
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 11 days later
Dear Dr XXXXXXX

Thank you for your XXXXXXX insight into this subject, it's very important to me and i am immensly grateful. i wish you could be kind enough to advise me further.


I would like to know if the exposure of 6 month course of oxandrolone has any 'lasting effect' on any area of the eye cells. You mentioned new cells are formed but i understand certain cells in the eye, for example lens, they stay for life...or is it otherwise?


And as for an activated androgen receptor, can future androgens bind again with the same receptor or does the old 'used' receptor degrade/die?


I wish you could help me further Dr XXXXXXX as i am concerned about any 'cellular lasting effects' of oxandrolone on non renewable cells such as eye.


Many thanks in advance .
XXXXXXX
 
 
Answered by Dr. Kulbir Singh 2 hours later
Hello XXXXXXX and welcome after a long interval
You are right the eye lens cell stays for life. But the process of binding does not take place in these types of cells. Every cell in our body has different structures and functions. So the cell for androgen receptor are different and receptors binding take place in that type of cells till the cell is alive after that new cell formed and binding take place in new cells.
That is the cause the side effects of the medication last for a limited period of time and duration. Every cell and every drug has different action of mechanism in different part of body. Some mechanism are still under research and yet to discover.

Hope you understand the thing and got your answer.
Regards
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 42 minutes later
Dr XXXXXXX I really appreciate your advice. I would like to ask further about 'drug action of mechanism' please.


As far as discovered and your good opinion, does a 6 month course of low dose oxandrolone have any intra-cellular lasting effects in any paart of body, or is it just temporary effects that cease because of new cells formed and therefore 'start again' free of effects of oxandrolone? Please advise as maybe my understanding is incorrect.

Best Regards,
XXXXXXX


 
 
Answered by Dr. Kulbir Singh 15 minutes later
Hello XXXXXXX
As I have already tells that the effect of oxandrolone is not permanent and they reduces with omitting of the drug. So in my opinion the lasting effect of the drug has no effect at cellular level at some stage after omitting the drug but it may require certain other medication or precautions for better and early process. Rest depends on the severity of side effect and immunity of the person.

If you have any temporary or permanent side effect from oxandrolone or any other drug than consult your treating doctor for its proper remedy and get rid from it. It can not cure by its own because formation of new cell also requires healthy environment in the body.

Regards
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 5 hours later
Thank you for your advise Dr XXXXXXX

Ok so we established stopping oxandrolone allows non-renewable cells to go back to normal, but what about in males endogenous testosterone (of which Oxandrolone is a derivative binding to androgen receptor) Doesnt the endogenous testosterone continue the actions of prior exogenous oxandrolone intra-cellularly? Please advise as maybe i have wrong understanding.

I took oxandroloone at 14.5 years and i am concerned about its impact on non renewable cells and areas of my body. i hope you feel what i'm saying,

Thank you Dr Kulbir
 
 
Answered by Dr. Kulbir Singh 10 hours later
Hello XXXXXXX
You have taken the drug about 15.5 years ago (do not know the cause?). So I do not think after such a long time you have any impact at cellular level. If it has than you must have facing some problems. At present stage your all cells are functioning normally if you are not on any medications or suffering from any disease whether they are androgen receptors or not. The drug taken 15.5 years back has now no effect on that and endogenous testosterone also continues there normal action.
Regards
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 5 hours later
Thanks again for your advice DR XXXXXXX I am very grateful for your feedback as I have no other way to clear this.


what about effects of the drug on the brain. I was at an age around pubertal/pre pubertal. What happens after endogenous testosterone begins to increase and acheives adult levels, whats the mechanism there pleasE?


There are androgen receptors in brain and brain cells doesnt renew.

Thanks in advance

Regards,
XXXXXXX
 
 
Answered by Dr. Kulbir Singh 13 minutes later
Hello again
First of all can you please tell me why you have taken this drug?
Is it prescribed to you by doctor or you take it by your own? If yes than why?
What are the symptoms present in you that drug is necessary to consume?

As I have told you previously that every cell has different function and non-renew cells does not participate in binding. so as per the brain cells are concern they does not participate in binding.

Hope finally you will understand else we need to talk, so please call me when ever possible.
Regards
Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 1 hour later
Thank you Dr XXXXXXX for your followup,

Well my doctor prescribed low dose oxandrolone for 3 months at 14.5 years old. This was to increase height because of my short stature. But it is suspected that i underwent spontaneous puberty because of rapid changes and Ox is too weak to cause such changes. May i provide the following extract from medical journal:

'It is proposed that there are three categories of receptors for androgen in the brain. One receptor preferentially binds testosterone and a second one preferentially binds DHT. Both of these receptors are in equilibrium between nucleus and cytoplasm according to the free water content of the compartments. Both of these receptors can be activated and transformed by steroid and thus concentrate in the nucleus'

The above suggests binding does take place in brain. Also i f i may ask, If binging doesnt take place in brain then how does androgens exert its effects on it? If you could clarify for me because i'm not in medicine. Thanks in advance and always grateful,

Best Regards,
XXXXXXX


 
 
Answered by Dr. Kulbir Singh 30 minutes later
Hello XXXXXXX
I think you have sufficient knowledge about the topic than me and I will not able to understand you after such a long conversation. It is better to read Harison medical book or pharmacological book to understand the mechanism of the drug. I told you that binding does not take place in brain cells not brain. Brain is a different thing and it receives all signal form our body and reacts to every signal as per needs. Brain cells also activates according to the need like vomiting will induce when vomiting receptors are activated. You are not vomiting all the time. Now you will ask what happen to these cells when you are not vomiting? and the queries goes on. I am sorry dear but neither I can answer your all queries nor your queries stops. I have written every think which I know. You can talk to your treating doctor who have prescribed you the medication for your further query.
Thanks for your time
Best Wishes
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
Follow-up: What are the effect of low dose testosterone on eye? 1 hour later
Dear Dr XXXXXXX i am really thankful for ALL your advice and clarifications in this subject. i think i follow . Androgen receptor in brain is different to androgen receptor within a cell cytoplasm? Is this what your advising doctor?

i fully appreciate your advice thats why i keep asking , and also because this was 15 years ago and i dont even know where the old doctor is or alive/dead i dont know....

So I want to close the subject. Can you reassure me please. I am now healthy and i feel healthy. Is there any presence of impact from this short course of oxandrolone in any area of my body. Are the androgenic effects occuring in my body today partly due to oxandrolone treatment at age 14.5? This is my final question, I wish u well doctor XXXXXXX

Best Regards,
XXXXXXX
 
 
Answered by Dr. Kulbir Singh 13 hours later
Hello XXXXXXX and thanks
In my personal opinion presently their no impact of the medicine taken 15.5 years ago. The drug has done its effects when you have taken it and I hope you also noticed the change in you at that time. Since now you are healthy and feeling good so make your mind relax and please do not go so XXXXXXX onto the mechanism. It will increase your stress and finally Blood pressure.
So in my opinion take the drug as per your doctor prescription as every doctor wants to help the patient, they never do wrong with you.
Regards
Dr. Kulbir Singh
Above answer was peer-reviewed by
 
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