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Taking Cymbalta and Abilify. What can I use for pain after surgery ?

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I'm a surgeon , My patient is taking Cymbalta and Abilify,
What can I use for pain after surgery ?
Posted Thu, 20 Jun 2013 in General Health
Answered by Dr. Jorge Brenes-Salazar 13 minutes later

Thanks for your query.

Essentially all narcotics can have an interaction with aripiprazole, in terms of increasing sedation and CNS depression. On the other hand, NSAIDs have an interaction with duloxetine in terms of increasing the risk of bleeding. The only pain medication that would not have an interaction is acetaminophen, but it is a weak analgesic.

So, all in all, it depends on the surgery performed and the expected levels of pain. If severe pain is experienced, then consider temporarily discontinuing the aripiprazole and using narcotics for the short term; conversely, if the pain is moderate, can consider holding the duloxetine and using NSAIDs, but the risk of bleeding and renal dysfunction could be increased. If there is no way that either medication could be held temporarily, then high dose acetaminophen up to 4 grams would be warranted.

Hope that helps, truly yours,

Dr Brenes-Salazar MD
Mayo Clinic MN
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