Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
199 Doctors are Online

Suggested to insert misoprostol pills into vagina. What are the side effects?

User rating for this question
Very Good
Answered by

General & Family Physician
Practicing since : 2004
Answered : 537 Questions
I am going to have a sonohysterogram tomorrow, and have been advised to insert some misoprostol pills into my vagina the night before (tonight). The effects and side effects that I have read here online from pregnant women who took these seem messy and painful. Should I expect the same even though I am not pregnant and only taking this drug for my exam?

I feel I should mention, that I am perimenopausal, and have had some irregular bleeding over the past couple of months. I also have two fibroids that were found during a pelvic sonogram. This is the reason that I am having this procedure. Just thought that this bit of background might help you in answering my question more specifically...
Posted Wed, 28 Aug 2013 in General Health
Answered by Dr. Sujeet N Charugulla 47 minutes later
Hello and thanks for your query.

I shall make an effort to provide you with good professional recommendations specific to your questions.

No. The answer is hence, because - Misoprostol's side effects that you may have read about mostly occur with oral pills with a dosage range of about 800 microgm daily over few days. But, your situation curtails a single pessary containing approx 400 microgm that is useful primarily for softening the cervix in order for the probe of the ultrasonography that has been planned for you to pass through without causing undue pain.

You need not be worried about this drug causing menstrual issues and other con
concerns in your history getting aggravated.

Let me know if I have missed out any other concern in your question.

Yet again, I duly appreciate your query to me, I do hope that you have found something useful to help you and I shall be glad to answer any further apprehensions.


Dr Sujeet N Charugulla,
Consultant Physician.
Above answer was peer-reviewed by
Follow-up: Suggested to insert misoprostol pills into vagina. What are the side effects? 9 minutes later
Thank you. You have put my very active imagination at ease. This is what I thought, but wasn't sure. My appointment is for tomorrow at 2PM. It is now 12:22AM. At what time should I insert these pills?

The directions on the bottle merely say "insert the night before," but since my appointment isn't until the afternoon, I'm not sure when to do this.
Answered by Dr. Sujeet N Charugulla 1 hour later
Thanks for your replies.

Usually the desired effect of vaginal dilatation is achieved when inserted about 3-4 hours before the procedure.

But, you may best check with the pharmacist, as this time slightly varies with manufacturer. Ask him to give you a time in hours rather than a nonspecific "a night before".

So, early morning insertion would be a good option by my opinion if your time is around 12 PM tomorrow.

Let me know of any further concerns.

Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Medical Topics

The user accepted the expert's answer

Ask a Doctor Now

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor