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Suggest Treatment For A CLL Patient Treated With Fludarabine Or Rituximab

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Posted on Mon, 3 Nov 2014
Question: Which prophylactic treatment are recommended for CLL patent treated with flurdarabine or rituximab? Why?

A. Patients should be given predrisone or dexamethasone to minimize the effects of tumor lysis syndrome.
B. Patients should be given predrisone or dexamethasone to minimize the effect od uremic-hemolytic syndrome.
C. Patients should be hydrated and given allopurinol or rasburicase to minimize the effects of uremic-hemplytic
D. Patients should be hydrated and given allopurinol or rasburicase to minimize the effects of tumor lysis syndrome
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Answered by Dr. Indranil Ghosh (1 hour later)
Brief Answer:
the answer should be D

Detailed Answer:
These newer therapies cause high rate of cell kill which can cause lot of tumor lysis.
Hence hydration and allopurinol are given prophylactically
Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1712 Questions

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Suggest Treatment For A CLL Patient Treated With Fludarabine Or Rituximab

Brief Answer: the answer should be D Detailed Answer: These newer therapies cause high rate of cell kill which can cause lot of tumor lysis. Hence hydration and allopurinol are given prophylactically