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Suggest An Alternative To Espazine Plus Tablet

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Posted on Wed, 19 Apr 2017
Question: Suggest alternative to Espazine plus tablet
Sir,
My wife aged 64 years DOB 15 XXXXXXX 1953 Height 5feet weight 55 kg was taking Espazine plus Tab with B'complex morning 1+1 and night 1+1 for the past 23 years. She under gone treatment from17-5-1988 to 23-5-1988 with 4ECT. Now the tablet is not available in the market so I consulted a DPM doctor at my town , he said it is old drug and is difficult to get the equivalent and suggested to take Trinicalm Plus TDS one tablet with zisper ls one at night. She takes Amryl m 1mg for sugar. Now after changing over from Espazine plus to Trinicalm plus the result is not satisfactory. Kindly sagest suitable replacement for Espazine plus so as to get correct treatment for her mental health please.
Thanking You
Yours sincearly
XXXXX
doctor
Answered by Dr. Seikhoo Bishnoi (50 minutes later)
Brief Answer:
Brand can be changed and this should help

Detailed Answer:
Hi, thanks for asking from healthcaremagic.com

I can understand your concern. Espazine plus is a brand of Galaxo and consists of Trifluperazine and Trihexyphenidyl. Tricalm plus also has same constituents. She is having poor results because of change in brand of the drug. This occurs because of change in bioavailability and pharmacodynamics in different brands.

You can try Neocalm Plus which is manufactured by Intas pharma and this should help her.

Instead of Ziper you can think of giving her Olanzapine in low dose. This will help in maintain sleep as well as psychotic symptoms.

For some days low dose Clonazepam can be used till she gets adjusted on Trinicalm Plus. This will help in reducing the withdrawal if any.

Thanks. Take care

You are welcome to ask follow up doubts.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Seikhoo Bishnoi (6 hours later)
Sir,
Thank you so much for your prompt reply . Kindly sagest me the correct potency with dosage and availability of Olanzapine to take along with Trinicalm plus so as let her start with the treatment . If this doesn't suits then I shall try with Neocalm Plus then let you know the progress and Kindly sagest me your contact particulars for further correspondence
Thank you
yours sincearly
XXXXX
0000.
doctor
Answered by Dr. Seikhoo Bishnoi (3 hours later)
Brief Answer:
Oleanz, Oliza, Olawave MD etc are common brands.

Detailed Answer:
Hello again

Olanzapine is available as Oleanz RT or Oliza or Olawave etc brands. Starting dose should be 5 mg after dinner and will help in sleep. If needed it can be increased to 10 mg per day. Most likely this will suit her. Stop giving Risperidone and continue with Trinicalm plus.

Thanks. You can contact again for more doubts.

Take care
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Seikhoo Bishnoi (11 hours later)
Sir,
Once again I am thanking you and request to give me 30 days for her treatment and let you know the result please.
XXXX
0000
doctor
Answered by Dr. Seikhoo Bishnoi (1 hour later)
Brief Answer:
Yes you can contact again after a month.

Detailed Answer:
Hello again,

Yes you can contact again after a month, no need to worry.

Continue with Oleanz 5 mg in night along with Trinicalm Plus as advised earlier for a month. She will do good with these medicines.

Thanks.
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5193 Questions

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Suggest An Alternative To Espazine Plus Tablet

Brief Answer: Brand can be changed and this should help Detailed Answer: Hi, thanks for asking from healthcaremagic.com I can understand your concern. Espazine plus is a brand of Galaxo and consists of Trifluperazine and Trihexyphenidyl. Tricalm plus also has same constituents. She is having poor results because of change in brand of the drug. This occurs because of change in bioavailability and pharmacodynamics in different brands. You can try Neocalm Plus which is manufactured by Intas pharma and this should help her. Instead of Ziper you can think of giving her Olanzapine in low dose. This will help in maintain sleep as well as psychotic symptoms. For some days low dose Clonazepam can be used till she gets adjusted on Trinicalm Plus. This will help in reducing the withdrawal if any. Thanks. Take care You are welcome to ask follow up doubts.