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Screening Test Done For Syphilis. What Are The Findings And Should I Go For Syphilis Shot?

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Posted on Tue, 19 Feb 2013
Question: hi I just had lab work done where i had high lipase 80 U/L an my hepatic function level ALT 41 U\L and AST 39 U/L and TSH 0.21 mIU/L and RPR titer 1:8 ... the first doctor send me to health department to get a syphilis shot but when I got there they said by these results where not enough to say I have syphilis that it looks like a false positive that my hepatic levels and alter the results if titer.. Can this be possible ??
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Answered by Dr. Sheeba Stephen (5 hours later)
Hello and welcome to Healthcare Magic. Thanks for your query.

RPR (Rapid Plasma Reagin) is a screening test for syphilis. However it is not a confirmatory test and there can be false positives. Some conditions which can give a false positive result are:

Lyme disease
Certain types of pneumonia
Malaria
Pregnancy
Impairment in Liver functioning
autoimmune disorders
Tuberculosis (TB)

A titre of 1:8 on an RPR is significant. Though it is possible that a deranged liver function can cause a false positive, in your case, your liver functions are only mildly deranged and may not be sufficient enough to cause a false positive.

In such cases, when there is a doubt, rather than just presuming that it is a false positive, it is better to do a confirmatory test for syphilis, such as TPHA or FTA-ABS. Please discuss this with your doctor.

Wish you all the best.

Regards,
Dr. Sheeba Stephen
Emergency Medicine Specialist
Note: Consult a Sexual Diseases Specialist online for further follow up- Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Sheeba Stephen

Emergency Medicine Specialist

Practicing since :2006

Answered : 300 Questions

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Screening Test Done For Syphilis. What Are The Findings And Should I Go For Syphilis Shot?

Hello and welcome to Healthcare Magic. Thanks for your query.

RPR (Rapid Plasma Reagin) is a screening test for syphilis. However it is not a confirmatory test and there can be false positives. Some conditions which can give a false positive result are:

Lyme disease
Certain types of pneumonia
Malaria
Pregnancy
Impairment in Liver functioning
autoimmune disorders
Tuberculosis (TB)

A titre of 1:8 on an RPR is significant. Though it is possible that a deranged liver function can cause a false positive, in your case, your liver functions are only mildly deranged and may not be sufficient enough to cause a false positive.

In such cases, when there is a doubt, rather than just presuming that it is a false positive, it is better to do a confirmatory test for syphilis, such as TPHA or FTA-ABS. Please discuss this with your doctor.

Wish you all the best.

Regards,
Dr. Sheeba Stephen
Emergency Medicine Specialist