Hello,
Thanks for posting your query.
The quad screening test (sometimes referred to as the quadruple screen, AFP4, or multiple marker) is a blood test that can tell you whether your baby is at an increased risk for certain problems. The conditions it screens for are Down syndrome and trisomy 18, which are chromosomal abnormalities, as well as neural tube defects, such as spina bifida.
The quad screen is done in the second trimester, usually between 15 and 18 weeks of pregnancy.
Harmony Prenatal Test with Y Analysis is a non-invasive test that detects fetal trisomies 21, 18, and 13 and analyzes the Y chromosome for any abnormalities.
The specific Y Analaysis is done as it can provide information on fetal sex and aneuploidy with 99% accuracy. X chromosome is present both in male and female fetuses.
Y aneuploidy is estimated to be present in approximately 1 out of every 1,000 male newborns. It is more common than other autosomal aneuploidies. So, it is preferred to do a Y chromosomal analysis also.
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Dr. Rakhi Tayal.

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Hello.
Thanks for writing again.
A positive Quad test for Down's syndrome means that levels of some or all of the substances measured in the blood were outside the normal range. This suggests the chances of having a baby with Down's syndrome are almost 80%. False positive can happen for various reasons, including:
A miscalculation of pregnancy time
A multiple pregnancy
In vitro fertilization
The presence of other medical conditions, such as diabetes
Smoking during pregnancy, etc.
Secondary tests like targeted ultrasound, chorionic villus sampling and amniocentesis are recommended to confirm if there is any chromosomal abnormality.
A heart beat of 155/minute is normal.
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Do accept my answer in case there are no further queries.
Regards

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HCG is a natural hormone that is present in the body during pregnancy. It is given in pregnancy to support the placental function. It is not responsible for Down's syndrome which is a genetic chromosomal defect.
Regards.

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Your wife had HCG injections till 12 weeks and she had a blood test at 15 weeks. The effect of these injections in blood does not stay for more than two weeks. These injections are not likely to cause a false positive result.
Regards.

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The hcg MoM value of 2.21 is increased. The DSR- Down's syndrome risk ( second trimester) is 1 in 62 which is suggestive of a positive test.
At such a high risk, it is best to go for more specific tests like amniocentesis and chorionic villus sampling under the guidance of your obstetrician to confirm the diagnosis.
Regards.

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