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Low Immunoglobulin, Red Dysmorphic Blood Cells In Urine, Stricture In Bulbous Urethra. Is It Thin Basement Membrane Disease?
Question: Please guide for following-
low Immunoglobin M- 0.36 g/L, Immunoglobulin G --12.04 g/L,Immunoglobulin A-- 3.75 g/L, Estimated glomerular >60, Calcium 2.37 mmol/L,Urea 6.4mmol/L,Sodium 142 , Potasium 4.6, Chloride 107, CO2 content 27,Creatinine serum 66 CRP 4.5 ,ESR 20 mm/Hr, previously ESR and CRP ARE HIGHER THEN THIS RESULTS, C4 0.43 G/L, C3 1.29 g/LBeta 2 Globulin 5.2 g/L, Gamma globulin 11.9g/L, Beta 1 Globulin 4.5g/L,Protein total 74 g/L, Albumin 41.9,
Alpha 1 and 2 globulin 2.7 and 7.7 g/L respectivly ANC Screen negative at 1:80, Hb 136,RBC 4.4 10E12/L,HBSAG nEGATIVE, PT/PTT - INR 1.0 ,PTT 31.2 SECONDS,hEPATITIES B surface Antigen EIA negative, Antibody to Hep C negative,
Nephrologist noticed red dysmorphic blood cells in urine. Nephrologist here give some idea of Thin basement membrane desease,even for this he is not sure,
Urologist have noticed large stricuture in bulbous urethera, not clear what to do with this.
Here in Canada,doctors are in position to diagnose any specific concerns,
Reports of blood tests,urine tests MRI,EMG,CT,U/S can be sent after getting your response
low Immunoglobin M- 0.36 g/L, Immunoglobulin G --12.04 g/L,Immunoglobulin A-- 3.75 g/L, Estimated glomerular >60, Calcium 2.37 mmol/L,Urea 6.4mmol/L,Sodium 142 , Potasium 4.6, Chloride 107, CO2 content 27,Creatinine serum 66 CRP 4.5 ,ESR 20 mm/Hr, previously ESR and CRP ARE HIGHER THEN THIS RESULTS, C4 0.43 G/L, C3 1.29 g/LBeta 2 Globulin 5.2 g/L, Gamma globulin 11.9g/L, Beta 1 Globulin 4.5g/L,Protein total 74 g/L, Albumin 41.9,
Alpha 1 and 2 globulin 2.7 and 7.7 g/L respectivly ANC Screen negative at 1:80, Hb 136,RBC 4.4 10E12/L,HBSAG nEGATIVE, PT/PTT - INR 1.0 ,PTT 31.2 SECONDS,hEPATITIES B surface Antigen EIA negative, Antibody to Hep C negative,
Nephrologist noticed red dysmorphic blood cells in urine. Nephrologist here give some idea of Thin basement membrane desease,even for this he is not sure,
Urologist have noticed large stricuture in bulbous urethera, not clear what to do with this.
Here in Canada,doctors are in position to diagnose any specific concerns,
Reports of blood tests,urine tests MRI,EMG,CT,U/S can be sent after getting your response
Dear XXXXXXX,
Low Immunoglobulins can be present in otherwise healthy individuals.
RBCs in the urine are of concern as these are dysmorphic RBCs which arise from within the kidney and not from the lower urinary tract. (Otherwise a urinary infection or the stricture might have been the cause for that).
Only way to confirm if it is actually thin basement membrane disease is by a kidney biopsy and electron microscopy.
Is there any protein in the urine?
What is your present TSH level?
Has your Vit D levels been checked, Symptoms could be due to deficiency!
The stricture in your urethra would not need any intervention if your urine flow is normal and no residual urine on ultrasound.
Hope this helps.
Regards
Low Immunoglobulins can be present in otherwise healthy individuals.
RBCs in the urine are of concern as these are dysmorphic RBCs which arise from within the kidney and not from the lower urinary tract. (Otherwise a urinary infection or the stricture might have been the cause for that).
Only way to confirm if it is actually thin basement membrane disease is by a kidney biopsy and electron microscopy.
Is there any protein in the urine?
What is your present TSH level?
Has your Vit D levels been checked, Symptoms could be due to deficiency!
The stricture in your urethra would not need any intervention if your urine flow is normal and no residual urine on ultrasound.
Hope this helps.
Regards
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Dear Dr XXXXXXX
Thanks for valuable guidance.
March 14,2012- TSH -6.40, Free T4 11.2
April 26,2012 -TSH 4.76, Free T4 10.9 pmoI/L, Thyroid peroxidase Antibody 7.2 KIU/lI will send all reports of blood and urine today, Not sure that Vit,D is checked or not, will see.
Regards.
XXXXXXX
Thanks for valuable guidance.
March 14,2012- TSH -6.40, Free T4 11.2
April 26,2012 -TSH 4.76, Free T4 10.9 pmoI/L, Thyroid peroxidase Antibody 7.2 KIU/lI will send all reports of blood and urine today, Not sure that Vit,D is checked or not, will see.
Regards.
XXXXXXX
Dear XXXXXXX,
TSH now is fine. Vit D levels are not checked routinely. However the importance of Vit D in many organ systems other than bone has been realised only recently. Deficiency is quite frequent esp places farther away from the equator.
Regards
TSH now is fine. Vit D levels are not checked routinely. However the importance of Vit D in many organ systems other than bone has been realised only recently. Deficiency is quite frequent esp places farther away from the equator.
Regards
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Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
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