Brief Answer:
Immunity is what helps individuals fight and survive infections

Detailed Answer:
Hello sir and welcome.

Thank you for writing to us.

I have gone through your query with diligence and would like you to know that I am here to help. I shall address all your queries in order, as you have written them sir.

1. "The infectologist said that reason why some people develop server invasive CA MRSA infection is weak immune system and some health problems, and those who are healthy but have some immune system defects !

(and also other medicine experts has the same opinion )"

Community-associated methicillin-resistant Staphylococcus Aureus (CA MRSA) can happen to anyone, although I do agree with your previous doctors about it being more common in individuals with lowered or poor immunity, but I agree with them only partially. CA MRSA is more commonly seen in individuals who live in crowded communities (e.g. slums, military camps, government hospitals, prisons, etc.) and are constantly exposed to contaminated items (food, drink, personal items, etc.).

So in a way, all the individuals living in such a setup are exposed to such situations wherein their immunity is indeed lowered, but there are different circumstances to this as well.

2. "And those who considers to be absolutely healthy and develop serve invasive CA MRSA infection have some immune system defect"

Yes, a few individuals who appeared to be healthy previously and are infected with CA MRSA have some immune system defect. But if you discuss the medical history of such individuals, you will find a long and frequent list of infections. So you cannot consider these individuals healthy at any point.

"that they seams absolutely healthy and when they got CA MRSA trough some cuts they develop serve invasive CA MRSA infections. "

Yes, when an absolutely healthy individual gets the invasive form of CA MRSA, it is more commonly due to innoculation through cuts, wounds, etc.

"And those who are healthy with good immune system will develop from CA MRSA skin infections that are easy treatable. "

No, CA MRSA starts off as a skin infection which can be suppressed, but the infection will not be easy to tackle or treat due to the already present methicillin resistance and lowered immunity. But if this individual is healthier than the others, and has a comparatively good immune system, they will respond better and will even recover completely and live a healthy life thereafter

3. "And if we are talking about CA MRSA that has PSM toxin – as I understand those with good immune system will develop skin infection that are treatable, but those with immune system defects and with health problems will develop severe invasive infections. "

Yes.

In conclusion, the main factor here is the individuals immune system. The immune system is the most important factor that helps to fight any infection, not just CA MRSA. Those individuals with a good immune system can fight the infection and be lucky enough to live, and those with a poor immunity do not have the strength to fight resistant infections like CA MRSA. That is why healthy individuals can survive and be easily treated and not those with some immunodeficiency (e.g. medications, HIV, etc.) or immune defect.

I hope you find my response both helpful and informative. I also hope I explained things in a manner best understood by you. Please feel free to write back to me for any further clarifications, I am always here to help.

Best wishes.

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Brief Answer:
Yes sir, I agree; I was explaining other scenarios, my apologies

Detailed Answer:
Hello once again sir.

Yes sir, you are indeed correct.

If an individual with severe invasive form of CA MRSA is detected, there will be some or the other immune condition as explained in my response no. 1. All the factors that I explained also contribute towards the development of lowered immune system.

As for the second part, you are right once again. If someone gets CA MRSA and approaches a doctor at the earliest, and also has a level of immunity that will help him/her to recover soon, then they can most certainly avoid the invasive severe form of CA MRSA.

All the doctors explained everything correct to your sir. The part which you did not understand was where I was providing other scenarios for also getting CA MRSA. :)

I am sorry if I did not explain that well enough to you sir, my sincere apologies. Please do write back to me for any further clarifications, I shall make sure I explain things in a manner best understood by you.

Best wishes.

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Brief Answer:
For monitoring response to medications and progress sir

Detailed Answer:
Hello once again sir.

Yes sir, the expected response if you report to a doctor early and have a good immune system, then you should be easier to treat and should be able to avoid the invasive and more severe form of the infection.

Yes, the invasive form does develop in immunosuppressed or immunodeficient individuals or those whose treatment has been neglected for a very long time resulting in weakening of the immune system.

Individuals with CA MRSA with skin infections need hospitalisation for monitoring. The individuals who have only the skin infections can be easily treatable, but if at all the medications prescribed are not working well and if this patient is in the hospital, we can observe that the current treatment is not helping and initiate different and better treatment to avoid this patient's condition from progressively getting worst, and to prevent this individual from getting the more severe form due to improper medication prescribed.

For this reason, to avoid any complications and to monitor their progress and improvement, it is important to hospitalise all/most of these patients, instead of sending them home and taking a chance. The patient when at home will not know accurately whether they are improving or not, and so this monitoring is best done in the hospital sir.

I hope I have explained things in a matter best understood by you. Please do not hesitate to write back to me for any further clarifications, I am always here to help.

Best wishes.

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Brief Answer:
Yes of course sir, anytime

Detailed Answer:
Hi sir.

Yes, of course. You can write to me anytime, and any number of times, please do not hesitate.

Best wishes.

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Brief Answer:
Yes sir, this author is also agreeing with all the other doctors

Detailed Answer:
Hello once again sir.

Yes, if you are healthy and if you reach your doctor on time then you should not have to worry about the invasive form of the infection.

The author here clearly explains that blood stream infections like MRSA are serious and occur a little more frequently in those individuals who have some other health problem, and less frequently in those individuals who are healthy.

In those individuals who ignore early symptoms and do not get treatment on time, they become immunocompromised (meaning they are also not considered healthy anymore) and these kind of people are difficult to treat and even at times develop the invasive form of the infection.

Those who develop blood stream infections fast or quicker than others are those who were not healthy before the MRSA infection started, these people develop the infection or get the infection quicker or faster than a healthy person.

Yes, this author is also saying the same thing, like all the other doctors. Just that he is explaining it in a slightly different way, but this author is also agreeing with all the other doctors sir.

Best wishes.

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Brief Answer:
I shall try my best

Detailed Answer:
Hi sir.

Yes, the author does mean that healthy people develop this infection a little less rapidly than those who are immuno-compromised or who have some underlying infection.

Yes, even the healthy people can develop this but mostly when it is grossly neglected. The rapid and invasive form can develop from negligence and not seeking medical attention early.

I will look for literature and send it to you as soon as I find something, but I would also like you to know that Doctors do not trust all the sites online, so I need some time to look for a legitimate and trust worthy site. Please send me your email id so I can send you the link once I find it and if I find something I like and want you to read.

Best wishes sir.

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Brief Answer:
I have read it on many instances, one example mentioned here sir

Detailed Answer:
Hello once again.

"Mild skin infections and even some moderate infections (boils, small abscess) can have an excellent prognosis if treated early and effectively. Other more serious or extensive MRSA infections have a range of prognoses (outcomes) from good to poor."

http://www.emedicinehealth.com/mrsa_infection/page10_em.htm

There are a few other sites that also state the same, but in different words and more elaborate explanations, but you can trust me when I say this that this is a proved fact and should be the case with all patients matching the criteria.

Best wishes.

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