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Is Fatigue, Muscle Tightness And Soreness A Side Effect Of HRIG And Rabies Vaccine?

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Posted on Tue, 1 Apr 2014
Question: What impact would injecting hrig and rabies vaccine in the same shoulder have on the effectiveness of the treatment? Is fatigue, muscle tightness and soreness a side effect of hrig and rabies vaccine?
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Answered by Dr. Praveen G (25 minutes later)
Brief Answer: One more shot of vaccine on to other shoulder. Detailed Answer: Hello, Welcome to HCM, It is my pleasure to answer your query, Antirabies vaccine and the rabies immunoglobulin (HRIG), should be taken at different sites. The ready made antibodies (HRIG) can neutralize the antigen of antirabies vaccine and may interfere in inducing protective rabies virus neutralizing antibody (RvNab) titres, if it is given in the same shoulder. I suggest you to take one more shot of antirabies vaccine on to other shoulder by intramuscular route and complete the full schedule of antirabies vaccination. The antirabies vaccine and human rabies immunoglobulins (HRIG) are very safe and they are known to cause minor side effects like pain and induration in the injection site. Hope you got the answer for your query, if you have any further questions I am very much happy to answer them. Thank you.
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Above answer was peer-reviewed by : Dr. Shanthi.E
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Dr. Praveen G

Infectious Diseases Specialist

Practicing since :2002

Answered : 2448 Questions

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Is Fatigue, Muscle Tightness And Soreness A Side Effect Of HRIG And Rabies Vaccine?

Brief Answer: One more shot of vaccine on to other shoulder. Detailed Answer: Hello, Welcome to HCM, It is my pleasure to answer your query, Antirabies vaccine and the rabies immunoglobulin (HRIG), should be taken at different sites. The ready made antibodies (HRIG) can neutralize the antigen of antirabies vaccine and may interfere in inducing protective rabies virus neutralizing antibody (RvNab) titres, if it is given in the same shoulder. I suggest you to take one more shot of antirabies vaccine on to other shoulder by intramuscular route and complete the full schedule of antirabies vaccination. The antirabies vaccine and human rabies immunoglobulins (HRIG) are very safe and they are known to cause minor side effects like pain and induration in the injection site. Hope you got the answer for your query, if you have any further questions I am very much happy to answer them. Thank you.