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Is eating grapefruit safe when on pravastin?

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General & Family Physician
Practicing since : 2005
Answered : 1766 Questions
I am on pravastin. Is it safe to eat grapefruit?
Posted Thu, 23 Jan 2014 in Hypertension and Heart Disease
Answered by Dr. T Shobha Deepak 1 hour later
Brief Answer: Not recommended to use simultaneously Detailed Answer: Namasthe Welcome to Healthcare-Magic Greetings of the day It is not advisable to take grape juice with pravastin. Grape juice inhibits the enzyme cytochrome P3A4 which is enzyme metabolising pravastin. Concomitant use will lead to elevated level of pravastin causing increased adverse effects including myopathy. In case you require any further assistance, will be glad to assist you. Take care Best Regards Dr T Shobha Deepak MBBS, MD
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