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Is Cymbalta intake advisable when suffering from liver disease?

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Internal Medicine Specialist
Practicing since : 2003
Answered : 873 Questions
my dads 84 and he went to diabetic doc yesterday. he's been taking Cymbalta for 5 yrs. his doc. didn't know about this. his liver enzymes were up and she said Cymbalta was the worst thing for liver. my mom has taken it for 1 year. she has chirosis of liver. my sis had a liver transplant recently and takes it. she said all her docs knew it and said it was safe. shes a psychologist and got my mom & dad on it. who is right? His doc. said we have to wean him and my mom off due to suicidal thoughts.
Posted Sat, 22 Feb 2014 in Liver and Gall Bladder
Answered by Dr. Vaddadi Suresh 49 minutes later
Brief Answer: I would recommend to keep away from cymbalta. Detailed Answer: Hi, Thanks for your query. Cymbalta (duloxetine) is not recommended in patients with liver diseases. (Canadian labeling says it is strictly contraindicated). I have no idea why your mom who has cirrhosis, is also kept on cymbalta. Another thing, it should also be used with extreme caution in kidney diseases. as there are many other alternatives for depression, i would recommend to keep away from cymbalta. Hope I am clear. All the best.
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Follow-up: Is Cymbalta intake advisable when suffering from liver disease? 7 hours later
What should I do about my sister since she had a liver transplant & all the Birmingham doctors know she's on it? And I guess, agree its okay!I was taking st johns wort for a year & ran out 3 months ago. I forgot to get some. My stress level is way up due to my aging parents. They fall all the time. I am now running my dads farm equipment business. My speech all of a sudden turned fast. My level of thinking moved up a notch and actually I've reached a different plane. I know it sounds crazy and due to my fast talking my family thinks I'm crazy. Although I know I'm not. But I figured out it all started when I quit taking the st johns. Now I'm back on it for 3 days now and find myself tapering off. My speech has slowed down. I don't want to entirely lose my "new" self. If that makes since. My decision making was much sharper during the 3 months. But my speech was getting faster & faster because my mind was working faster. My lips couldn't keep up with my mind. I couldn't get my thoughts out fast enough. Does any of this make sense without having me committed(LOL) I'd rather not take lexopro,prozac nor cymbalta. I want to be able to think clearly while taking care of my parents. My parents are trying to get me on cymbalta to SLOW me down. I refuse, due to the problem it has caused them! Is st. johns okay?
Answered by Dr. Vaddadi Suresh 3 hours later
Brief Answer: she can continue the drug cymbalta. Detailed Answer: Hi, Your first question: As your sister has a new functioning liver, she can continue the drug cymbalta. Your second question: St johns is proved to be much safer than conventional antidepressants like cymbalta. The change in the speech after you were off the drug was just withdrawal symptom. you get over once you sustain it for sometime. Your determination and idea to remain drug free is appreciable. I would suggest you to continue st johns for some more time, taper it over few weeks or months and once you feel confident, stop it; rather than stopping it all of a sudden. you have options like yoga and meditation which will surely help you to keep away from drugs, yet with reasonable success. The decision to either start or not, cymbalta or any other psych drug is better made by your doctor rather than your parents or yourself. Hope i am clear. Feel free to put you queries. Bye.
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Follow-up: Is Cymbalta intake advisable when suffering from liver disease? 3 hours later
I understand completely now. Had my sister not had the transplant, and had been taking cymbalta, it would NOT have been good. Correct? I printed off the info under this site on what major drugs interact with cymbalta.(www.drugs,com) It is 210 & 733 moderate. I showed my parents & intend to show my "psychological" sister before she intervenes again. At one time she had them on lexapro. I wish she'd quit "playing" doctor with my parents. I do appreciate your time. You've been most helpful. And too, I will have an experts advice to show my parents & sister. This site ( WWW.WWWW.WW has been most helpful. Thank you sooooo much! My husband is the one who told me about this site and he even suggested me ordering a yoga dvd and try at home. He is a recovering alcoholic. I will definitely spread the word!
Answered by Dr. Vaddadi Suresh 19 minutes later
Brief Answer: You are absolutely correct. Detailed Answer: Hi, You are absolutely correct. All the best for you and your parents' health. Your rating would be greatly appreciated while closing the post. Thank you.
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Follow-up: Is Cymbalta intake advisable when suffering from liver disease? 4 hours later
How about this...My Dad uses those diabetic needles. He throws them on the florr after using them(with dried blood on them). Keep in mind that he's 84. I guess that's as good of an excuse as any. One day I was cleaning his floor, I stuck an old bloody needle between my thumb nail(it stuck hard). I pulled it out and my blood poured out. I wrapped it. That was 2-3 months ago. My thumb no longer hurts at the nail, but it hurts terribly in the joint near my wrist. Please don't tell me to go to the doctor due to my deductible being $3000 due to this Obama plan. I had a urine test done for a physical for my CDL's. Would Hepatitis c have shown up? I guess I could donate blood to really see. I am a female, 51, in good health, 6' tall, 153#. I battled a boyfriend with cirrhosis of the liver due to hepatitis c(he Took the injections to get rid of the hepatitis). He's out of my life. I got checked for that and at that time didn't have hepatitis c. To battle that and to get it from an 84 yr. old father would be rather ironic! Can you understand why I'm a little stressed? No, I only drink about 6 beers a week(if that many). This will probably be the last question I bother you with. I do have a business face book page if you would "LIKE" it. It is under Whitworth Farm Equipment & Trailer Sales. Thank you again! धन्यवाद!
Answered by Dr. Vaddadi Suresh 3 hours later
Brief Answer: I can bet you won't get hep C Detailed Answer: Hi, i do understand your situation. I can bet you won't get hep C. The reason is the blood from needle stick of a thin diabetic needle is less than 1/100th of a drop, which barely contain virus. Secondly, thin layer of blood quickly dries, the virus immediately dies in contact with air. So you really have NO reason to worry. All the best.
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