Question: I recently experienced a thermal burn, second degree, on top of my right foot. I initially took a Codeine pill from a past prescription to deal with the pain, as well as a Vitamin E gel tablet (400 IU), and a "One a Day" vitamin pill. Within 24 hours the foot started to swell and became red despite elevation, so I took one Benadryl tablet, and started using Bacitraycin as an ointment. I subsequently visited the doctor, who changed the bandage and put me on Cephalexin, two 500mg capsules every 12 hours, and Oxycodone/APAP 5-325mg every 4 - 6 hours. I also received a tetanus shot as a precaution. I returned to the doctor's office two days later for another dressing change. The surrounding redness had not subsided, so I was given two shots of antibiotic. I returned the next day for another dressing change The redness had begun to subside. To help speed up the healing of the wound I was referred to the local wound care clinic. By this time I had been on Oxycodone for about four days and realized that I had been experiencing some of the less common side effects: neck and stomach pains, and high anxiety. I immediately stopped usage and switched to Ibuprofen the next day, taking three 200 mg tablets over the course of six hours. After taking the last tablet I started experiencing behavioral changes: crying over past memories and high anxiety again. I have ceased ALL medications at this point - including the vitamin pills - since the foot is healing well now and the pain is tolerable. I have not used any drugs for about four days now, except for my daily dosage of high blood pressure medicine - 10mg of Lisinopril. How long before the side effects of Oxycodone subside? I read that certain vitamins and medications interact very poorly with Oxycodone. My anxiety, crying, and depression are slowly subsiding. Thank you very much for your reply!!!!! Sincerely, XXXX