Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
192 Doctors are Online

Have rheumatoid arthritis. What is the cause for enlarged spleen and high blood cell?

User rating for this question
Very Good
Answered by

General & Family Physician
Practicing since : 2001
Answered : 11951 Questions
I am very frightened. High white blood cell count resulted in referral to hemotologist/oncologist who found enlarged spleen but said lymph nodes not swollen. He mentioned lymphoma - sent me for ultra sound. I have rheumatoid arthritis take enbrel and methotrexate still fighting copd symptoms and asthma flare that started in Nov. Is there a chance that this is the result of arthritis and meds?
Posted Thu, 24 Jan 2013 in Arthritis
Answered by Dr. Michelle Gibson James 4 hours later
Hi, thanks for using health care magic

It is natural to frightened if you are unsure of the reasons for abnormal blood tests.

Rheumatoid arthritis can be associated with some changes in the full blood count. In terms of the white cell count, it can cause, in rare cases, mild elevation of the white cell but the elevation, if it does occur, is usually mild.
It would not be significant enough to have warrented further investigation.

The enbrel can be associated with a decrease in the white cell count. In extremely rare cases (only a few persons have been identified), this family of medication is associated with a type of lymphoma.As stated, this is a rare occurence.

Methotrexate can also be associated with decrease in white cell count, not usually an increase because it suppresses the body's ability to carry out certain functions.

The spleen has 4 basic functions and any abnormality of these functions can sometimes lead to enlargement.
The functions are (1) removal of any abnormal red blood cells from the blood
(2) producing some substances that are used in the immune system
(3)clearing certain organisms or bacteria from the blood
(4) producing red blood cells in some conditions

Enlargement of the spleen may or may not be significant.

I hope this information is helpful and everything works out for you.
Feel free to ask any other questions

Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Lab Tests
Medical Topics

The user accepted the expert's answer

Ask an Orthopaedic Surgeon

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor