Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
166 Doctors are Online

Does tamoxifen raise CEA levels ?

User rating for this question
Very Good
Answered by

Practicing since : 2004
Answered : 1212 Questions
I finished chemo(TCH) for breast cancer node negative,2.4cm, no lymphovascular invasion 12 weeks ago.Had Pet scan prior to surgery and was ok.My CEA was only(.7) with the tumor inside (had bilat mastectomy).
During chemo was 1.3, 1.1 and 1.0 then 6 weeks after chemo 2.7, 3.7, 3.6 and today 5.4. Upper normal limit is (5) in my lab. ca 15.3 has been from 5.3 to 9.5 and UNL is 32. I had second PET 4 weeks ago and was ok, no uptake. showed some inflammation around the mastectomy scars. I started Tamoxifen just after the 2.7 reading. My oncologists said that Tamoxifen can raise CEA along with the residual inflammation seen in PET. She is not worried but I am.Do you think this is significant despite recent negative PET? how come CEA was so low with the tumor still inside, wouldn't it have been elevated back then? Do you agree with tamoxifen being able to cause this elevation now a bit over limit/
Posted Fri, 13 Apr 2012 in Breast Cancer
Follow-up: Does tamoxifen raise CEA levels ? 1 hour later
correction:surgery was 9 months ago, second PET, 4 weeks ago
Answered by Dr. Indranil Ghosh 14 hours later

Thanks for posting your query.

It is good to know you are doing well. You have early node-negative breast cancer and received herceptin also.

The results of the test are not significant. I agree with your oncologist comments. They are not concerning to me. These tests are not recommended for follow up of breast cancer, more so for early stage (Ref NCCN, ASCO & ESMO guidelines for management of breast cancer).

I advise you to get back to your normal lifestyle as early as possible. Maintain healthy diet, do regular exercise and keep body weight as normal as possible.

Hope I have answered your query. Should you have any more concerns, I will be available to answer them.

Above answer was peer-reviewed by
Follow-up: Does tamoxifen raise CEA levels ? 3 hours later
how about CEA being so low preop with the tumor still inside, also, I remember having lot of leg musle pain probable myosists/myalgia 3 weeks after chemo and lasted 1 month. can this kind of inflammation also can raise CEA? my biggest concern was that during chemo CEA was low. I appreciate
Answered by Dr. Indranil Ghosh 11 hours later

Thanks for writing again.

Sometimes inflammatory or infective disorders can raise the CEA.

It is a non-specific test and does not help in this scenario. Go through this excerpt from the American Society of Clinical oncology (ASCO) guidelines..."Carcinoembryonic antigen (CEA) is not recommended for screening, diagnosis, staging, or routine surveillance of breast cancer patients after primary therapy" (Ref Lyndsay XXXXXXX et al. Journal of Clinical Oncology Nov 2007).

Hope my answer is helpful.

Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Diseases and Conditions
Medical Procedures

The user accepted the expert's answer

Ask an Oncologist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor