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Does Alcohol Interact With Bactrim?

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Posted on Tue, 24 Jan 2017
Question: I was just put on Bactrim DS today for a UTI, but I am a drinker and found I can not drink alcohol with it. Is there an antibiotic that would allow me to drink ? I will be going into outpatient rehab in a few weeks but can't stop cold turkey right now.

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Answered by Dr. Muhammad Ahmad (3 hours later)
Brief Answer:
If your liver is fine you can continue.

Detailed Answer:
Hello,

Thanks for writing to Health Care Magic, I am Dr Muhammd Ahmad, I have closely read your question and I understand your concerns, I will hereby guide you regarding your health related problem.

Your medicine contains a combination of SULFAMETHOXAZOLE/TRIMETHOPRIM these drugs have NO interaction with ethanol what so ever, problem is expected only when the patient has alcoholic liver disease. So if your liver is doing fine and there are no previously known damaging effects of alcohol on your liver then you do not have to change medication in my opinion.

But if liver is not well functioning then almost all the antibiotics given for this problem will be having exaggerated side effects, in that case only, you will have to reduce your alcohol intake if you can not get rid of it completely. But currently if there are no liver issues, you are good to go.


I hope this answered your question, if you have more feel free to ask,otherwise close the discussion and rate it.

Regards.

Dr.Muhammad Ahmad.
General and Family Physician..

Above answer was peer-reviewed by : Dr. Nagamani Ng
doctor
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Follow up: Dr. Muhammad Ahmad (7 hours later)
What about the fact that tremethoprim impairs the breakdown of acetylaldehyde. This is the mechanism that Antabuse uses to discourage drinking.
doctor
Answered by Dr. Muhammad Ahmad (6 hours later)
Brief Answer:
It has action like Disulfiram. Quite Rarely though mild.

Detailed Answer:
Hello ,

Thanks for writing back, I do understand what are you pointing to. Actually the drug disulfiram is used for alcohol abuse and that drug causes acitaldehyde accumulation in the body causing reaction to ethanol.

If you consult reliable text books of pharmacology or reliable internet based information like Medscape you will realize that there is no considerable interaction between trimethorpim and ethanol.

Yes it is thought to have Disulfiram LIKE action some times but this property of it is quite rare and way down the list of disulfiram like drugs. In studies as well only 2-3 percent of patient had reactions taking Trimethorpim and Ethanol together. There is absolutely no recommendation in pharmacological text books to avoid the drug if one uses alcohol, but yes if you happen to get any reaction like hot flushes sweating etc. then you can stop the drug.

There are many myths and discussion on the internet about it but according to reliable medical literature, there is no significant interaction between the two.

If you still have doubts and want to know about possible change in medication then please tell me about your case in detail i'll further guide you.

Best regards.

Dr.Muhammad Ahmad.

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Above answer was peer-reviewed by : Dr. Arnab Banerjee
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Answered by
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Dr. Muhammad Ahmad

General & Family Physician

Practicing since :2012

Answered : 1308 Questions

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Does Alcohol Interact With Bactrim?

Brief Answer: If your liver is fine you can continue. Detailed Answer: Hello, Thanks for writing to Health Care Magic, I am Dr Muhammd Ahmad, I have closely read your question and I understand your concerns, I will hereby guide you regarding your health related problem. Your medicine contains a combination of SULFAMETHOXAZOLE/TRIMETHOPRIM these drugs have NO interaction with ethanol what so ever, problem is expected only when the patient has alcoholic liver disease. So if your liver is doing fine and there are no previously known damaging effects of alcohol on your liver then you do not have to change medication in my opinion. But if liver is not well functioning then almost all the antibiotics given for this problem will be having exaggerated side effects, in that case only, you will have to reduce your alcohol intake if you can not get rid of it completely. But currently if there are no liver issues, you are good to go. I hope this answered your question, if you have more feel free to ask,otherwise close the discussion and rate it. Regards. Dr.Muhammad Ahmad. General and Family Physician..