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Does Trazodone Interact With Tramadol And Amlodipine-Besylate?

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Posted on Fri, 26 May 2017
Question: I have a question: I'm not sure IF I should take the AMLODIPINE BESYLATE 2.5 AND TRAMADOL 50 MG - 1 TABLET TWICE DAILY ( NOW REPLACES TRAZODONE - THE TRAMADOL SCARES ME - HAVEN'T TAKEN IT YET)
WHICH MY PHARMACIST SUGGESTED THAT I DISCUSS THIS WITH MY DOCTOR BEFORE TAKING THESE!! I HAD ALREADY TAKEN THE AMLODIPINE BESYLATE FOR THE PAST 22 DAYS AND AFTER READING THE PATIENT PRESCRIPTION IINFORMATION I'M NOT SURE THEY ARE SAFE. I'M VERY CURIOUS AS TO WHY I AM SUPPOSED TO TAKE THESE.




INFORMATION I'M NOT SURE
AFTER READING THE PATIENT PRESCRIPTION INFORMATION I DON'T KNOW IF
THESE ARE SAFE!!!
I FORGOT TO MENTION I INJECT 25 UNITS - TWICE DAILY OF NOVOLOG 100 UNITS/ML FLEXPEN ALS0 LEVIMIR FLEXPEN 100 UNITS/MLL - I INJECT 35 UNITS TWICE DAILY.
doctor
Answered by Dr. Panagiotis Zografakis (43 minutes later)
Brief Answer:
there are some concerns

Detailed Answer:
Hello,

I understand that you don't take trazodone now and you want to start tramadol.
The only significant concern with tramadol is hydroxyzine. Both drugs may cause sedation (central nervous system suppression). In some cases the effect may be overwhelming for the patient and may even cause respiratory problems.

Trazodone with tramadol is a bad combination as it may - rarely - cause a serious side effect (serotonin syndrome) which is potentially fatal.

There is no problem with amlodipine.

You have not revealed the reason you need tramadol, so I can't comment any further on that. Tramadol and trazodone are different types of drugs. We don't use them interchangeably.

I hope you find my comments helpful!
Kind Regards!
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3809 Questions

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Does Trazodone Interact With Tramadol And Amlodipine-Besylate?

Brief Answer: there are some concerns Detailed Answer: Hello, I understand that you don't take trazodone now and you want to start tramadol. The only significant concern with tramadol is hydroxyzine. Both drugs may cause sedation (central nervous system suppression). In some cases the effect may be overwhelming for the patient and may even cause respiratory problems. Trazodone with tramadol is a bad combination as it may - rarely - cause a serious side effect (serotonin syndrome) which is potentially fatal. There is no problem with amlodipine. You have not revealed the reason you need tramadol, so I can't comment any further on that. Tramadol and trazodone are different types of drugs. We don't use them interchangeably. I hope you find my comments helpful! Kind Regards!