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Does Paxil Reduce The Effects Of Methamphetamine?

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Posted on Mon, 12 Oct 2015
Question: I can't get a meth high while using Paxil 40mg. Any advice?
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Answered by Dr. Seikhoo Bishnoi (42 minutes later)
Brief Answer:
Paroxetine is known to reduce efficacy of Meth.

Detailed Answer:
Hello thanks for asking from HCM for your health related queries

I can understand your concern. Paxil is Paroxetine and the drug is a SSRI drug. Meth or methamphetamine causes dependence and effects by many mechanisms and neurotransmitters like Dopamine, Serotonin, GABA etc are involved. Though research studies are not there that show reduction of efficacy of Meth while on paroxetine, but in some cases SSRIs are used to reduce use of Meth in some patients.

So yes Paxil in high dose might reduce the efficacy of Meth. Best thing that can be used in such case is to ask your doctor and discuss about reducing the dose of Paxil. Dose reductions to 20 mg per day will help in reducing the negative effects of serotonin blockage on Meth and this will help you. Consult your doctor before making any change in your prescription.

Thanks, Hope this helps you. Please don't hesitate to ask again for more doubts.

Take care
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Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Seikhoo Bishnoi

Psychiatrist

Practicing since :2007

Answered : 5193 Questions

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Does Paxil Reduce The Effects Of Methamphetamine?

Brief Answer: Paroxetine is known to reduce efficacy of Meth. Detailed Answer: Hello thanks for asking from HCM for your health related queries I can understand your concern. Paxil is Paroxetine and the drug is a SSRI drug. Meth or methamphetamine causes dependence and effects by many mechanisms and neurotransmitters like Dopamine, Serotonin, GABA etc are involved. Though research studies are not there that show reduction of efficacy of Meth while on paroxetine, but in some cases SSRIs are used to reduce use of Meth in some patients. So yes Paxil in high dose might reduce the efficacy of Meth. Best thing that can be used in such case is to ask your doctor and discuss about reducing the dose of Paxil. Dose reductions to 20 mg per day will help in reducing the negative effects of serotonin blockage on Meth and this will help you. Consult your doctor before making any change in your prescription. Thanks, Hope this helps you. Please don't hesitate to ask again for more doubts. Take care