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Does Metrodanizole Cause Progressive Polyneuropathy?

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Posted on Mon, 27 Jan 2014
Question: Could my use of Metrodanizole several times in 2012/2013 be responsible for my progressive polyneuropathy I am experiencing now. Onset was abrupt. I am not diabetic. The neurologist said it was likely small nerve neuropathy. But when I emailed her recently to tell her the neuropathy was ascending to my calves, thighs, and lower back, her only response is to throw one more 800mg dose of Neuorntin into my daily bid dose EMG studies, ABI's were all negative. The pain is excruciating. I am very concerned that it will progress to my thoracic area as I have COPD/Emphysema
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Answered by Dr. Sudhir Kumar (5 hours later)
Brief Answer: My reply is below. Detailed Answer: Hi, Thank you for posting your query. Neuropathy caused by metronidazole would not be progressive, especially if you are not using metronidazole any more. It should get better over time, since the last use of metronidazole. Therefore, we need to look for alternative causes for neuropathy, such as CIDP (chronic inflammatory demyelinating polyradiculoneuropathy), vasculitis, etc. The diagnosis can be confirmed by doing a sural nerve biopsy. With appropriate treatment, we can stop the progression, and recovery can also occur over time. You can continue to use neurontin at this stage. I hope my answer helps. Please get back if you have any follow up queries or if you require any additional information. Wishing you good health, Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist Apollo Hospitals, Hyderabad, India Click on this link to ask me a DIRECT QUERY: http://bit.ly/Dr-Sudhir-kumar My BLOG: http://bestneurodoctor.blogspot.in
Above answer was peer-reviewed by : Dr. Raju A.T
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Dr. Sudhir Kumar

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Practicing since :1994

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Does Metrodanizole Cause Progressive Polyneuropathy?

Brief Answer: My reply is below. Detailed Answer: Hi, Thank you for posting your query. Neuropathy caused by metronidazole would not be progressive, especially if you are not using metronidazole any more. It should get better over time, since the last use of metronidazole. Therefore, we need to look for alternative causes for neuropathy, such as CIDP (chronic inflammatory demyelinating polyradiculoneuropathy), vasculitis, etc. The diagnosis can be confirmed by doing a sural nerve biopsy. With appropriate treatment, we can stop the progression, and recovery can also occur over time. You can continue to use neurontin at this stage. I hope my answer helps. Please get back if you have any follow up queries or if you require any additional information. Wishing you good health, Dr Sudhir Kumar MD (Internal Medicine), DM (Neurology) XXXXXXX Consultant Neurologist Apollo Hospitals, Hyderabad, India Click on this link to ask me a DIRECT QUERY: http://bit.ly/Dr-Sudhir-kumar My BLOG: http://bestneurodoctor.blogspot.in