Brief Answer: A rare possibility of false possitivity is there. Detailed Answer: Hi, Welcome to HCM. Thanks for posting your query. Concomitant Cold virus or other viral infections can cause a false a false positive RNA PCR in the absence of HIV infection, but very very rare, less than 1%. It is better for you go for this test a week after the complete cessation of cold infection. Dr S.Murugan

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Brief Answer: 4th generation test after 12 weeks conclusive Detailed Answer: Hi, Welcome back. Once again I ascertain that the chances for false positive results in presence of any viral infections with HIV RNA PCR test is very very rare. In my experience with RNA and DNA PCR results in HIV diagnosing, I am yet to come across such an incident. These tests are highly reliable and specific. Regarding the fourth generation combo/duo test (both antigen/antibody detection test), if done 12 weeks after the high risk sexual activity it is almost 100% reliable as it detects both antigen and antibody (HIV 1&2) simultaneously and if it is done earlier, then once again as an isolated antigen detection test it can show a remote chance of false positivity. HIV 2 infection which is also very rare other than in Africa likely to be missed as most of the antigen test (RNA PCR) detects only HIV 1 alone. Dr S.Murugan

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