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Can Indomethacin Be Taken With Levofloxacin?

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Posted on Mon, 16 Jun 2014
Question: My husband is taking a 7 day perscription of Levofloxacin 500mg. He is on day 3. Can he take Indomethacin 500mg at the same time?
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Answered by Dr. Michelle Gibson James (1 hour later)
Brief Answer:
potential risk of seizures

Detailed Answer:
HI, thanks for using healthcare magic

Levofloxacin belongs to the fluoroquinone family of medication and indomethacin belongs to the NSAID family.

There is a potential interaction, it may or may not occur.

Using Fluoroquinolones and NSAIDS together increases the risk of stimulation of the central nervous system due to displacement of certain chemicals. There is a potential risk of seizures but this risk would be greater in persons who have a history of seizure disorder.

Normally the combination would be used with caution and monitored.

If there are no other pain medication options that your husband and doctor are able to use then it can be used and he would monitor for any issues.

If it is possible to use pain medication from a different family that would be best.

I hope this helps, feel free to ask any other questions
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Can Indomethacin Be Taken With Levofloxacin?

Brief Answer: potential risk of seizures Detailed Answer: HI, thanks for using healthcare magic Levofloxacin belongs to the fluoroquinone family of medication and indomethacin belongs to the NSAID family. There is a potential interaction, it may or may not occur. Using Fluoroquinolones and NSAIDS together increases the risk of stimulation of the central nervous system due to displacement of certain chemicals. There is a potential risk of seizures but this risk would be greater in persons who have a history of seizure disorder. Normally the combination would be used with caution and monitored. If there are no other pain medication options that your husband and doctor are able to use then it can be used and he would monitor for any issues. If it is possible to use pain medication from a different family that would be best. I hope this helps, feel free to ask any other questions