Get your Health question answered in 3 easy steps
A Doctor will be with you shortly
Ask a Doctor Now
188 Doctors are Online

Blood test showed enlarged RBC but folate and B12 normal. Have extreme tiredness. Suggest?

User rating for this question
Very Good
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2305 Questions
HI. In a recent blood test my red blood cells were enlarged but my folate and B12 levels normal. I am suffering from extreme lethagy and tiredness which is preventing me from working. I have obstained from alcohol for one month but the extreme tiredness remains. Do you have any suggestons? Thanks desperate
Posted Fri, 19 Jul 2013 in Medicines and Side Effects
Answered by Dr. Prasad 4 hours later

Thanks for writing here.

Macrocytosis or enlarged red blood cells is generally seen in vitamin B12 and folic acid deficiency when DNA synthesis is impaired. I am glad to know that folic acid and vitamin B12 deficiency are ruled out.

Apart from the usual vitamin deficiencies, a few other conditions are noted to cause macrocytosis. Hypothyroidism is one amongst those conditions.

Since you also report of extreme lethargy and tiredness, it may be part of depression. However as underactive thyroid state also causes lethargy and tiredness, I would suggest you to get your thyroid hormone checked.

You are encouraged to consult a hemotologist who can consider hypothyroid state and the other possible conditions. He/she can subject you to relevant investigations which can get to the root of this problem.

I hope this helps. Let me know if you need clarifications.

Above answer was peer-reviewed by
Share on Facebook
Share on Twitter
Share on Google+
Question is related to
Medical Topics

The user accepted the expert's answer

Ask an Internal Med Specialist

© Ebix, Inc. All Rights Reserved.
All the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. You should always speak with your doctor before you follow anything that you read on this website. Any health question asked on this site will be visible to the people who browse this site. Hence, the user assumes the responsibility not to divulge any personally identifiable information in the question. Use of this site is subject to our Terms & Conditions
Already Rated.
Your rating:

Ask a Doctor