What does "white matter changes confluent in frontal parietal" mean? - Online Doctor Chats
Hi. My name is XXXXXXX Had MRI done that showed diffuse white matter changes confluent in frontal parietal areas bilaterally. Leukoencephelopathy was mentioned. Bloodwork only revealed high antithyroid antibodies. MRI done 1 year later showed no changes. I am greatly concerned about the word leukoencephelopathy being mentioned. Currently suffer anxiety and depression. I am 35 years old.
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Ok Gone through it
Now you should be happy that the repeat MRI had no changes
Why was it concerning you
The word diffuse and the word leukoencephelopathy
Ok but anti thyroid antibodies indicate some kind of autoimmune process in your body
Could hashimotos cause such white matter changes. It was high about 1000
since they have probability of involving other systems the word diffuse
What is 1000? Anti peroxide antiboides??
Antithyroid antibodies were
Just an antithyroid antibody screen
But I didn't have major symptoms for hashimotos encephelopathy
Depression has to be immediately treated
Depression is known to show certain changes in the MRI brain
Ok what have the doctors done now
Even diffuse? To me diffuse means scattered and a lot
it is scattered but may not be lot
Left it up to me to get an opinion somewg
I am positive because the follow up MRI is clear and was it done at the same centre with previous MRI in place
What about ms in those lobes?
Did the previous radiologist attempt to see the previous one before opinion
Yes done at same place
Yes he did
MS also cause white matter changes put the description would be (plaques)
Please remember MS is still a clinical diagnosis
and MRI is just to see the extent
I read something about that genetic diffuse leucoencephelopathy and that scared me! Would it present like that?
Ok I am not up to date on that
As far as I know granuloma, infections, ischemic changes and any degeneration will be reported like this
I thought they were mot
What is mot
I am sorry I did not understand
I thought they were more focal less ions rather than diffuse
yeah in your report it is confined to only fronto parietal part
Yes so focal is worse or better than diffuse findings.
I think there is still a good prognosis
because the MRI changes did not progress or disappeaared
So in your opinion what can this possibly represent
The prognosis did not depend on focal or diffuse
Could I have been born with this since there is no comparision
In my opinion it is an immune mediated process
with evidence of antithyroid antibody
and the process flares sometimes
and sometimes it does not
No comparison to a previous MRI from while back
so the first MRI was taken when there was a flare or attack
of the antibodies against the white matter
Yes and a year later it showed the same thing with no changes noted
and the next time there was no action of antibodies
and so no changes
Get a autoimmune profiling done
No the mris presented the same. They both looked the same
I think I did
pANCA, RF factor, ANA, AntidsDNA
He checked for lupus did something called alpha beta gamma, Ana, cmv,
No not yet
Hey did you lose weight
No memory loss?
yea you do not sound
Any other medicines?
Were some steroids tried like Predinosone
Are you with me?
I am Dr. XXXXXXX here
Hi. What kind of doctor?
I am a Physician. I see you been chatting with another doctor. I shall transfer to him.
Ok thank you
Hi, I am Dr. Mazumdar here.
It's still me regarding the MRI of brain
So I was asking about your medications and if you were put on steroids?
Why do the neurologists check antithyroid antibodies regarding brain mri
No wasn't on any
Would there have been changes on my MRI after a year if it was something serious like leukoencephelopathy
But what really does it have to do with the brain MRI? Could hashimotos diseas really have caused that? By the way my tsp was normal
Most leukoencephalopathy are slowly progressing
there may only be negligible difference
I meant tsh was normal
So it may be leukoencephelopathy then. Aren't they deadly with no cure??? That's why I'm freaking out!!
I understand that completely
Not all of them are deadly
Most of them have cure
when the cause is found
If nothing is found a simple steroid is in practice
Which kind are not? What can cause them other than drugs
to stop the changes
Steroids will stop the demylenation?
I am unsure how much percentage is deadly but very low
Have you ever seen people with that
only once during my initial training years
though i could not follow the person
But your problem is still not a mystery
Oh so u don't know how he made out?
I hope your right.....do u think I should do any more testing if I'm asymptomatic?
If I were your treating doctor, I would not
I keep a close watch on even simple symptoms
Do u know if the drug accutane can damage the brain.
Was on it twice in past
I mean was it oral or application
It is commonly used drug and if damages it would be banned by now
However amongst the rare side effects stoke was mentioned
So how r most leukoencephelopathys treated
Yes I know about stroke
plus the cause of the leukoencephalopathy
What are some causes
I already mentioned those
Infections, granuloma, autoimmune
Sorry.....so that's why he checks antithyroid antibodies
What's a granuloma
a reaction to agents like TB, Sarcoidosis
I dont think so
Bp is great
So is cholesterol
ok I have used up my ideas to find out the cause then
Try to see if you can get some messages from here
Would u think hashimotos disease can do this.
Yes but no other symptoms
puts me on back foot with TSH normal
Get the other tests done
Not really other than depression and anxiety
Depression has the potential
Thank you for being with me
It seems we are short of time
Ok. All in all do u think it is something curable if it is somthing
Bye for now
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