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Treatment for fibroblast - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Growth and Development in Children
Answered by

General & Family Physician
Practicing since : 2004
Answered : 37 Questions
User :   my son has dozens of keloids, and more forming. at first from acne but now appears to be coming from no where. he has joint pain and fatigue also
is being treated for Lyme and taking doxyclyine
Doctor :   Hi
Doctor :   let me read your query
User :   also he is seeing a dermotologist . cordisone shots caused flare up in Lyme
Doctor :   may i know your sons age ?
Doctor :   and when did this problem start ?
User :   using Ethromycin on face (liquid) my son is 16
User :   joint swelling and headace 7 yrs ago.
Doctor :   ok, so he has acne for which he uses erythromycin
Doctor :   ok
User :   keloids 2 years ago- yes he has acne
Doctor :   so totally how many keloid does he have ? and may i know the location of the keloids ?
Doctor :   are they situated on the face ?
User :   he has at least 3 dozen, so far none confirmed on face although he thinks he is getting one there-he has them on shoulders, chest- chest being treated with liquid nitro
Doctor :   occurance of keloids is genetically determined
User :   i have heard this- husband amer indian black and irish- does not know of anyone with this in family
Doctor :   the healing fibroblasts are stimulated to proliferate in excess , which results in keloids
User :   how can we stop or treat them safely- could these collectively be symptoms of another problem ie. disease
Doctor :   usually the keloids can be resected surgically ,.,
Doctor :   but the chances of recurrances is high
User :   i am told they can and often return with a vengence
Doctor :   the best method is via cryotherapy
User :   is that liquid nitrogen? He is having that done on the smaller ones. the ones on his back are size of small grapes
Doctor :   yes cryotherapy is done using liquid nitrogen
User :   I am anxious as he appears to be getting more just erupting from skin with out appearance of acne
User :   could this be allergy related
Doctor :   no
Doctor :   this is not due to allery at all
User :   is there a particular palce for me to take him for treatment. live in NY upsttae
Doctor :   Keloids often run in families. Keloidosis is a term used when many or repeated keloids occur.
User :   how can we stop it? How long will this continue to occur?
Doctor :   some cases can be helped by injection of steroids (triamcinolone ) in to the keloids
Doctor :   the severe cases are helped by cryotherapy, laser therapy ,
Doctor :   in some cases, radiation also works
User :   we tried this and it caused extreme pain in his lyme artritis. missed 2 weeks of school. took 3 weeks to begin to feel better. is lazar therapy better than surgery. I asked dermolotgist about radiation but he did not seem to know of it. When do we get to this level? is it dangerous
User :   I meant we tried the coridisone injuections
Doctor :   yes laser is always better than surgery
Doctor :   also Imiquimod cream, can be used to prevent keloids from returning after surgery to remove them.
User :   what is recurance rate on lazar , especially being he can't take sreoids, right now I amm trying silicone on larger ones. What is emiquimod creme
Doctor :   this is a cream that helps to reduce the immune response and decreases the rate of fibroblast growth
User :   could my son have an autoimmune disorder? I have wondered
Doctor :   no
Doctor :   this is not a sign of autoimmune condition
Doctor :   this is just a form of over active tissues
User :   I feel like his body is attacking him- head, acne,joint,fatigue,stomach ache, bouts of contipation (bthis better now)
Doctor :   growing in excess due to genetic pattern in the fibroblasts
User :   is there a way to suppress this ? diet changes? vitamin minerals?
Doctor :   i do understand your pain and am sorry for that
User :   This poor kid, skin issues, asthma,lyme....
Doctor :   keloids cannot be prevented by any treatment that is available right now
Doctor :   BUT , You can prevent discoloration from sun exposure by covering the forming keloid with a patch or Band-Aid, and by using sunblock when spending time in the sun.
Doctor :   Continue these extra protection measures for at least 6 months after injury or surgery for an adult, or up to 18 months for a child.
User :   how long do you wait for treatment (cyr) to work before you try lazer
User :   i meant liquid nitrogen treatment
Doctor :   please wait for atleast 6 months
User :   ok he goes every 3 weeks for nitro treatment
Doctor :   the other treatment that can be used is interferon alpha injections
User :   what is that? is it steroids
Doctor :   no it is a cytokine hormone, that inhibits fibroblast growth
Doctor :   its not a steroid
User :   is it safer than radiation
Doctor :   sometimes in severe cases combination of laser, steroid injections and also treatment with a antimetabolite drug (5 fluorouracil) can be used
Doctor :   interferon is not safer than radiation
Doctor :   it has some significant side effects , and can cause exacerbation of conditions like TB, chronic infections, etc if a patient has them
Doctor :   but the need will be determined by a doctor keeping in mind all the clinical facts
User :   have you ever treated anyone with so many keloids? his dermo. is 72 and says he has never seen anyone this bad before
Doctor :   5 flurouracil, is a medication that reduces cell replication
Doctor :   there have been rare cases where i have encountered such cases
User :   is the 5 flouracil safe?
Doctor :   it is safe when taken under medical supervision
User :   how long did problem last. will he stop producing these?
Doctor :   it is not dangerous to life, but it is a good drug to help in cases where it is needed
Doctor :   keloids are not curable, sorry to say
Doctor :   i hope you have followed my comments
Doctor :   take care and bye for now
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