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Side effects of weight loss pills - Online Doctor Chats

Date : 13-Jan-2012
User rating for this question
Excellent Posted in: Medicines and Side Effects
Answered by

General & Family Physician
Practicing since : 2008
Answered : 3558 Questions
User :   Hi i am 23 and female.

I've been taking sibutramine 8.37mg for about three weeks but i didnt like the feeling of fast heartbeat and headache, so i reduced the dosage to about a half or may be 60 percent (by splitting the tablet). after doing so, i felt much better.

After i read online about the heart risks of sibutramine, i decided to get rimonabant (acomplia). i would like to know its drug interaction with Sibutramine. i wont be taking sibutramine in combination with rimonabant but what im concerned is that sibutramine has a long half-life and i was not sure how long i have to stay away from sibutramine before i start taking rimonabant.

my question is : how many hours should elapse between stopping sibutramine and starting rimonabant.

Also, wonder if rimonabant is as effective as sibutramine, phendimetrazine, or phentermine. and i would like to know if there is any kind of food that i have to be careful with rimonabant.
I'd appreciate it so much if i could get the answers

Thank you sososo much!


Doctor :   Hi
User :   Hi
Doctor :  
Let me read it to be able to answer you better
Doctor :  
Please give me few minutes
User :   yes thank you
Doctor :  
Yes you are right Sibutramine affects heart
Doctor :  
and Rimonobant is no safer
Doctor :  
It has psychiatric side effects
User :   are you serious??
Doctor :   Yes

Doctor :  
It is already banned in some countries
User :   yeah i know.... about psychiatric effects... but all diet pills relating to brain has that kind of problem.. so that was the only choice left for me..
User :   but i got it somehow
Doctor :  
Now let us get back to your problem first
User :   but havnt started on it
User :   yes
Doctor :  
What is you objective of taking these pills , Weight loss
User :   yes..
Doctor :  
What is your age, height and weight
User :   i am 23, 5'5" and 105 oiunds
User :   pounds
Doctor :  
According to the WHO guidelines and the US Dept of Health, you are just very fine
Doctor :  
with you weight
Doctor :  
In fact you are less than the ideal
User :   yeah but i still want to lose weight and i am really really serious..
Doctor :  
Ok
Doctor :  
I can help you
Doctor :  
But before that I shall explain you the unpleasant effects if you lose more, Do you
Doctor :   Do you want to look healthy or do you want to look just fine
User :   i want to look normal but to me my body looks fat
Doctor :  
Do you vomit after eating food?
User :   no never..
Doctor :  
Do you have regular menstrul periods?
User :   yes
Doctor :  
Ok fine
Doctor :  
Why do you rely on these weight loss pill and deteriorate your health condition
Doctor :  
Instead you can lose weight healthy with good diet and exercise
Doctor :  
and less side effects
User :   yeah i am really scared of losing my health but i am trying to do it in the most careful way.. that is why i am tryng to avoid sibutramine..
Doctor :  
In fact no side effects
User :   i do exercis
Doctor :  
Do not take Sibutramine and Rimonobant or any others
Doctor :  
Surely you get addicted to them
Doctor :  
and you shall certainly have harsh affects on health
User :   i exercse almost everyday but it is hard to go less than the weight i am at now and ifeel like i am getting fatter and fatter... it gives me so muh pressure
Doctor :   Your thoughts might give you more problems in future
Doctor :  
So you need help in relating your thoughts
User :   will it affect my pregnancy in the future even if i quit later
Doctor :  
One thing pregnancy might not occur if one is underweight
Doctor :  
or over weight
Doctor :  
Always measure your weight in terms of BMI
Doctor :  
Body mass Index
Doctor :  
and ideal range of BMI is 18.5 t0 25
Doctor :  
Your current BMI is 17 which is touching the grossly underweight category
Doctor :  
so you go into risk if you lose more
Doctor :  
Please try to understand
Doctor :  
if your thoughts are really concerning that you look fat
User :   i wont lose more than 5 pounds..
Doctor :  
Still it is not recommended
User :   this might sound weird to other people but my boyfriend pressures me to stay skinny and there is nothing i can do about it
Doctor :  
Ok if you want to stay skinny then this is not the right way
Doctor :  
You may adopt a weight loss program
Doctor :  
with diet
User :   i am a very careful person and i look up for information online if there is any problem or concern. i will stop when i start to feel weak or something
Doctor :  
The information available online is not customised
Doctor :  
it is general and it is just only 1% of the realty
Doctor :  
so you fall a trap to the info available so you have to be aware of those risks
User :   the problem is
User :   if i stop sibutramine.. my hunger will come back and start to gain more weight
User :   i was originally 100 pounds
User :   but my friends made me eat
User :   so i gained 5 pounds
User :   so i wanna lose that 5 lb
User :   i ont be going under that weight
User :   wont
Doctor :  
Ok
Doctor :  
So if you do not have those extra calories soon you will come back to 100 pounds
Doctor :  
Is it not?
User :   yeah but you know that stopping the medication will make me eat more
User :   my body will try to make me ear 10 times the amount i usually do if i stop
User :   eat
User :   soplease
User :   i paid money for this.... and i need to know how long i have to be away from sibutramine before i start takin rimonabant
Doctor :  
Now I have told you the effects of Sibutramoine
Doctor :   You should be away for 48 to 72 hours
Doctor :  
to completely lose
Doctor :   metabolize the sibutraine
Doctor :  
*mine
User :   i see.. and also a question about phendimetrazine..
Doctor :  
and then start on Rimonobant
User :   thanks
User :   i heard that phendimetrazine makes me release more dopamine and noeadrenaline
User :   so i was wondering if dopamine will increase serotonin as well as they try to balance each other
Doctor :  
Yes
User :   so phendimetrazine affects serotonin as well?
Doctor :  
YEs
Doctor :  
These are inter related
User :   also... i found out that rimonabant can cause alzheimer's disease
User :   is it proven?
Doctor :   yes it acts on cannabinoid receptors

Doctor :  
Some studies say that alzheimers is a future problem
User :   yeah but still.. ive seen people with that and i got all shocked
Doctor :  
Yes
User :   whats the chance of getting that disease (%)
User :   is it low or high?
Doctor :  
I have no idea
Doctor :  
but I can tell you after some study
User :   yes please
Doctor :  
So your question is, what percentage of people will be affected by Alzheimer's after using Rimonobant
User :   yes yes
User :   and also, i heard that rimonabant lowers blood pressure and keeps me away from heart problems. is it true?
Doctor :   No much evidence on it

Doctor :  
and the studies have not said any thing about the percentages of the Alzheimer's
User :   i see...
User :   and will rimonabant be as effecive as other drugs (sibutramine, phendimetrazine, and etc)
Doctor :   Cannabinoid receptor antagonists are helpful in treating the alzheimer's
Doctor :  
Yes
Doctor :  
when it is launched it was thought to revolutionize the obesity treatment
User :   yes
Doctor :  
later more trials found it to be as risky as others
User :   could you summarize those?
User :   ive already seen some on the internet but still would like to know
Doctor :  
Yes
Doctor :  
Did you read this statement
Doctor :  
patients who took 20 mg rimonabant for 1 year were then re-randomized to either continue on rimonabant, or to switch to placebo. Patients who stayed on rimonabant for the second year maintained the same degree of weight loss (they did not lose additional weight,) while those switched to placebo gained weight. At the end of 2 years, patients who took rimonabant for one year and placebo for the second year had about the same amount of overall weight loss as patients who took placebo from the beginning.
User :   no havent read but thank you
Doctor :   All this data is on the Obese people
Doctor :  
but I cannot relate it to you
Doctor :   The weight loss achieved with rimonabant is highly significant, statistically. But in magnitude, it's just not that great.

Doctor :   This info might be of some help to you
Doctor :  
A 20 pound weight loss (and 3 inches off the waist) after two years might not even be particularly noticeable in many of them. This drug simply does not take obese people and make them svelte; that's not what it does. It helps - but most of the real help appears to be metabolic. The metabolic improvement is very important. But this stuff won't make you skinny.
Doctor :  
I think you can take a best opinion from our panel of Neurologist
User :   then it is not as potent as phendimetrazine or sibutramine or phentermie?
User :   i can talk to them now?
Doctor :   WWW.WWWW.WW Doctor :  
You will get a reply within 24 hours
Doctor :  
All your questions are related to Neurology
User :   thank you so much !!
Doctor :   Pleasure speaking to you
Doctor :  
Please fill the feedback form say ddone when done

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