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Immuoglobins are very low 5 to 6 - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Blood Disorders
Answered by

General & Family Physician
Practicing since : 2008
Answered : 3341 Questions
User :   I had a blood test done and it showed that all my immuoglobins are very low 5 to 6 count,what is causing this/
Doctor :   Hi
Doctor :  
Doctor :   let me read yiur query
User :   hi
Doctor :   can you explain the tests done ?
Doctor :   and the specific immunoglobulins that were checked ?
User :   immoglobin a g m com total ch50 taken do to chronic sinus infections
Doctor :   please mention your age
User :   48
Doctor :   have you had any symptoms ?
Doctor :   can you explain why the tests were done in the first place
User :   sinus infections sore joints some timmes
Doctor :   HOW Long have you had these symptoms
User :   sinus infections on and off last 3 years they return after antibiotic treatment
Doctor :   how many episodes have you had in the past 1 year ?
User :   5 or 6
Doctor :   are they very severe ?
User :   yes
Doctor :   in that case, if you have low Immunoglobulin levels, this could be due to lowered production by the white cells
Doctor :   can you tell me how are the cell counts in a complete blood count ?
Doctor :   Are you there ?
User :   wbcx 10 3=6.5 w 26.5 mchc 33.8bcx 10 6=5.42 hemoglobin 14.4 hematocrit 42.5 mcv 78.4 mch
Doctor :   the normal WBC count is b/w 4000 - 0000 cells /CMM
Doctor :   so your counts are normal
Doctor :   has a differential counts been done
Doctor :   please mention the lymphocyte counts
User :   whats that
Doctor :   lymphocytes are a form of WBC
Doctor :   these cells produce antibodies
Doctor :   or immunoglobulins as they are called
Doctor :   Hi
Doctor :   Are you there ?
User :   yes
Doctor :   welcome back
Doctor :   presence of low lymphocyte counts can be associated with low antibody production
Doctor :   this can cause recurrent bacterial infections including sinus infections
Doctor :   sinus infections are caused by capsulated bacteria ( Streptococci )
User :   test orded where tsh cbc sed rate crp antidna antibod rheumatoid fact aena ccp complement c4 hla b27
Doctor :   what were the results of the tests ?
User :   c3 was high 189 alt(sgpt) high 83
Doctor :   what about the sed rate ?
User :   sed rate was 10
Doctor :   so a differential test were not done ?
Doctor :   ok it is normal
Doctor :   i mean the SED RATE
Doctor :   AND I assume all the other tests are normal ?
Doctor :   You might benefit by doing a electrophoresis of immunoglobulins test
User :   rdw was15.8 high
Doctor :   this will help to know which exact immunoglobulin is low
Doctor :   that is fine , i mean the RDW
User :   a g m all showed very low
Doctor :   ok
Doctor :   in that case, you might be having condition called AGGAMMAGLOBULINEMIA
Doctor :   where in there is reduced production of the precursor of antibodies
User :   whats that, i have a appt with immunoligist march 28th just wounderd how serious this is
Doctor :   this results in lack of production of A , G & M antibodies
Doctor :   this is not that serious, or life threatnening
User :   is ivig the only treatment
Doctor :   but it results in recurrent infections with encapsulated bacteria
Doctor :   yes IVIG would be the best treatment here
User :   what further test should i request
Doctor :   not much tests needed
Doctor :   as we know what immunoglobulins are missing
User :   what would of caused this now in life
Doctor :   any form of viral infection or bone marrow destruction could have destroyed the plasma cells within the bone marrow
Doctor :   these are the cells which produce the immunoglobuolins
Doctor :   or any defect in the synthesis of enzymes, that help in processing of the antibodies
User :   does this mean i will need bone marrow test
Doctor :   if not done already, yes you will need that
User :   whats it called
Doctor :   this is a bone marrow aspiration test
Doctor :   they aspirate the bone marrow from your hip bone
Doctor :   and then they examine it microscopically
User :   my hip has been hurting off and on for a month or two bad sign
Doctor :   that does not matter
Doctor :   it could be due to arthritis
User :   thanks
Doctor :   you are most welcome
Doctor :   thanks for consulting me here
Doctor :   take care and have a good day
Question is related to
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