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Fever,fatigue and headache with neurofibromatosis - Online Doctor Chats

Date : 13-Jan-2012
User rating for this question
Very Good Posted in: Brain and Spine
Answered by

General & Family Physician
Practicing since : 2004
Answered : 37 Questions
Doctor :   hi
Doctor :  
how can i help you?
User :   Hi is it Doctor
Doctor :   Yes, please proceed with your health query

User :   do u remember me
Doctor :   have you had the suggested checkup for your tumors?
User :   yes
User :   i went to the general physician yesterday
Doctor :  
yes i remember. Did you go for the FNAC?
User :   i showed him the tumors on my arm and some other places he just seen them and touched them and said it was neuro fibromatisis
Doctor :  
ok
User :   he told it is not cancer no tests required
Doctor :  
ok
Doctor :  
so now you are releived from one doubt
User :   ya
Doctor :  
next left to be done is the karyotypinf for both of you
Doctor :  
*karyotyping
User :   and for my headache he written master checkup to know more details
Doctor :  
ok
Doctor :  
so when are you going for that?
User :   but just touching them can we tell it is neuro fibromatisis
User :   becuase he has not done anything else just seen and touched and told
Doctor :   yes we can , we doctors have the experience and practice to see , touch and tell

Doctor :  
and neurofibromatosis is very easy and common to doagnose
User :   ok i will go for karyotyping some time next week
User :   and for neuro fibromatisis can i know more details
Doctor :  
good
Doctor :  
what details do you want to know?
User :   thans becuase of you i got the dare and went for checkup yesterday
User :   like my parets doesnt have them , and i too not observed them till 22 years
Doctor :  
its is fine, i apppreciate your decision to go for a checkup
Doctor :  
atleast now one big headache is off from you? isnt it?
User :   after my 22 years suddenly one after other i observed 3 in arms and one in back near to spinal card
Doctor :  
its is ok.
Doctor :  
i will tell you in detail about this problem
Doctor :  
this is a genetically-inherited disorder in which the nerve tissue grows tumors (i.e., neurofibromas)
Doctor :   that may be harmless or may cause serious damage by compressing nerves and other tissues.
Doctor :   The disorder affects all neural crest cells
Doctor :   Neurofibromatosis is autosomal dominant, which means that it affects males and females equally and is dominant
Doctor :  
which means only one copy of the affected gene is needed to get the disorder
User :   so my children will get 50% chace to inherit
Doctor :   Therefore, if only one parent has neurofibromatosis, his or her children have a 50% chance of developing the condition as well.
Doctor :   yes you are correct
Doctor :  
but another fact is that in around half of cases there is no other affected family member because a new mutation has occurred.
User :   and if a person doesnt have by birth this prblem and is it possible to develop this when he grows
Doctor :   yes it is possible due to mutations to develop it later in life
Doctor :  
which is what most probably happened in your case
User :   i think so
Doctor :  
and so you developed it after 22 years of age
Doctor :  
and nothing was there before that
User :   ya
User :   some fever and headaches and tierdness
User :   then after 6 months some color change on skin
User :   and then later 2,3 months i observed this
Doctor :  
yes i remember you told me all this yesterday
User :   this all happend when i am 20-22
User :   my headache and tierdness are because of this neuro fibromatisis
User :   ?
Doctor :  
we cannot say for sure
Doctor :  
it will depend on what kind of the neurofibromatosis you are having
User :   one more thing yesterday i had 140/100 BP which is not normal for my age doctor said
Doctor :  
neurofibromatosis is of 3 types
Doctor :  
yes it is high for your age
Doctor :   you will need to control salt in diet
Doctor :  
and start taking medications
Doctor :  
when are you starting your master health check?
User :   i have gievn samples yesterday
Doctor :  
ok
User :   reports will come in 2 days
Doctor :  
ok
Doctor :  
so we wil wait for the reports to come
Doctor :  
then see what can be said
User :   the doctor said forget about neuro fibromatisis , it is not danger and not cause anything
Doctor :  
ok
User :   ya you are saying in types of neurofibratisis
Doctor :  
if it is Type 1 neurofibromatosis, you do not need to worry
Doctor :  
in case of Type 2 neurofibromatosis
Doctor :  
you need to evaluate the headcahes
Doctor :   as these ones are known to cause headaches due to small tumors in the nerves entering or leaving the brain
Doctor :  
so for this a MRI brain might be needed to rule out possibilities of the tumors in brain and nerves entering and leaving brain
Doctor :  
headaches are more common with associated hearing loss in people with Type 2 disease
User :   i done have any hearing loss
Doctor :   another type is called Schwannomatosis
User :   perfectly god in hearing
Doctor :   these develop on cranial, spinal and peripheral nerves.
Doctor :   ok
Doctor :  
then no need to worry , but still the headaches need to be evaluated more
Doctor :  
the lesions due to the third type of disease leads to chronic pain, and sometimes numbness, tingling and weakness.
Doctor :   Neurofibromatosis type 1 is due to mutation on chromosome 17q
Doctor :   Neurofibromatosis type 2 is due to mutation on chromosome 22q
Doctor :   both are autosomal dominant disorders
Doctor :  
meaning that only one copy of the mutated gene need be inherited to pass the disorder.
User :   so definately now i have some chromosomal abnomralities
Doctor :   A child of a parent with NF1 or NF2 and an unaffected parent will have a 50%-100% chance of inheriting the disorder, depending on whether the affected parent is heterozygous or homozygous for the trait.
Doctor :   yes, based on this detail you do have a chance of having a mutated gene
User :   ok
Doctor :  
and the karyptyping will show you what exactly it is
Doctor :  
and if this was the real cause for the cystic hygroma in the baby
User :   if it is 2nd type is it serious
Doctor :  
Type 2 is a little serious
Doctor :  
and I am more concerned now as you do have headches
Doctor :  
so these headaches need to investigated in detail
Doctor :  
with MRI brain and neck
Doctor :  
so see if any such tumors are present
Doctor :  
which migh be causing the headaches
User :   if it is the reason is it life threating or we can control
Doctor :  
ask your doctor to include MRI brain and neck for you in the master check up
Doctor :  
the result of which wil tell you whether there is really soething to worry about
Doctor :  
or we can relax
Doctor :  
*something
Doctor :  
incase the MRI shows a tumor of neurofibromatosis developing is a crutial place in brain which might affect you later or affect any cranial nerves, then you might heve to undergo a operation to remove the tumor
Doctor :  
in case the MRI comes back normal, with no such finding to woory about
Doctor :  
we can leave the tumors alone
Doctor :  
have you followed what i have said?
Doctor :  
is there anything else you would like to know about them?
Doctor :   are you there?
Doctor :   have you followed what i have said?

Doctor :   are you there?
Doctor :  
are you there?
Doctor :   I have to close the window as you are not responding. Please chat with our doctors 24/7 for medical queries.
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