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Difference between polycythemia vera and mastocytosis - Online Doctor Chats

Date : 13-Jan-2012
User rating for this question
Good Posted in: Blood Disorders
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2408 Questions
User :   hello?
Doctor :  
how can i help you
Doctor :   hi
User :  
i have a question regarding the difference between polycythemia vera, and mastocytosis (systemic), like how would the lab values differ?
Doctor :  
are you there
Doctor :   Polycythemia vera is a blood disorder in which the body makes too many red blood cells

Doctor :   Mastocytosis is a disorder occuring in children due to excess production of mast cells

User :   yes but i also know that there is a basophil --> histamine release --> pruritis
User :  
etc
User :  
its not just in children thought i ask b/c my mom whos 55 was diagnosed with it
Doctor :   it is common in children
User :   ok
Doctor :   In polycythemia vera the total redblood cell count will be high

User :  
ok, but as for symptoms, ulcerations, histamine release
User :  
are they similar with regards to their symptoms?
Doctor :  
Symptoms of polycythemia vera is bluish discoloration of skin , red skin spots, dizziness, headache etc
Doctor :   In mastocytosis there is more production of mast cells

User :  
isnt that similar to the urticaria pigmentosa
Doctor :  
the mast cells are released in the body in response to any allergic reactions
User :  
ok
User :   her basophil count is high as well
Doctor :   Urticaria pigmentosa is a severe form of allergy and occurs in response to allergens

User :  
and since polycythemia vera is multipotent, could there as well be a increase in mastcells, since they are a type of granulocyte?
User :  
hence the urticaria pigmentosa wouldnt that be seen from polycythemia vera as well from its degranulation of the basophils ->histamine release?
Doctor :   but poly cythemia ther eis increase in red cells not white cells
User :  
then how do u have the increase Basophil count?
Doctor :  
mainly redcells
Doctor :  
as i explained you it will produce all the cells in excess
User :  
so its possible to have an increase in mastcells as well correct?
User :  
(pertaining to vera?_
Doctor :   Mast cells are produced as a response to some reaction
User :   but if you have masto, its just an increase prolif of mastcells, right? just like with polycytemia vera of the multipotent?
Doctor :  
yes
User :  
so knowing this
User :  
besides checking her blood values, like RBC increase, HB increase, Hg increase, etc, is it possible she could have this instead?
Doctor :   she also should be bonemarrow biopsy which is confirm the diagnosis

User :  
for the systemic portion of masto
User :  
ok
User :   now can masto --> AMl?
Doctor :   i thing you are getting confused a lot

User :  
how so?
Doctor :  
since you are jumping your queries form one disease tot he other which is completely different
User :  
how am i jumping form one to another
Doctor :  
let me explain you mast cells resemble the basophil cells, atype of white blood cell
User :  
my origional question was comparing the 2 diseases
User :  
i understand that
Doctor :  
but it is not a white blood cell
User :   its under a WBC
User :  
your right
Doctor :  
it is similar in structure to granulocyte
User :  
its from a granulatcyte
Doctor :  
and the mast cells are produced in reponse to the a reaction like allergy
User :  
granulcytes are eosinophils, basophils, neutorphils
Doctor :  
and they fight against it
User :   they release histamine
User :  
just like basophils
User :  
mastcells are the "tissue" derivitive of a basophil
User :  
I ask the AML question becuase i know that polycytehmia vera can --> AML
Doctor :   mast cells are structurally similar to basophil and originated from different parent cell in the bone marrow

User :  
i was wondering if masto does this to, b/c it as well is myloid in nature
User :  
im aware of this
Doctor :   i think you have half knowledge of every thing
User :  
im really not missing anything
User :  
what am i confused with
Doctor :  
you are not clear in what you want to know
User :   ok let me explain it again
Doctor :   ya sure

User :  
is it possible, for mastocytosis to eventually --> AML
Doctor :  
Mastoctytosis cannot turn to AML, the polycythemia can turn to AML
Doctor :   mastocytosis mainly causes skin lesions

Doctor :  
are you there
Doctor :  
are you there
Doctor :   I have to close this window since there is no response from your side, we are available 24/7 please get back to us if you need further medical advice.

Doctor :   hi
User :   sorry
Doctor :  
how can i help you
User :  
um
User :  
i just talked to you like 5 min ago
User :  
i think
User :  
or myabe your another doctor
Doctor :  
no iam the same doctor
User :  
ok
Doctor :  
you can proceed with your query
User :  
so i understand about the skin form of masto, but im refering to the systemic form
User :  
-->AML
Doctor :   it can present the features similar to AML

User :  
like a translocation?
User :  
15-17
Doctor :   are you there
User :  
yes
User :  
i asked about if it is similar because of translocation?
Doctor :   First thing polycythemia is more prone to become AML

Doctor :   iam unaware what type of translocation of chromosome that occur in AML caused by mastocytosis or polycythemia

User :  
15-17
Doctor :   ok]

Doctor :   are you there

Doctor :  
are you there
User :  
yes
User :  
ok
Doctor :  
you can proceed
User :  
so masto--> cml would be inconclusive at this point
Doctor :  
Yes
User :  
ok
User :  
thank you very much, sorry for racking your brain
Doctor :   it is Ok

Doctor :   Is there any thing else I can help you with?

User :  
no thankyou
Doctor :   Please fill the feedback form say done.Please fill the feedback form say done.
User :  
what kind of doctor are you
Doctor :   I am a General Practitioner
User :  
ah, where are you from?
Doctor :  
User :  
cool
User :  
one of my good friends is from there
User :  
we go to med school together
Doctor :  
ok
Doctor :  
fine
User :  
thankyo
Doctor :  
are you a doctor
User :  
im in med school, hopefully soon
Doctor :  
ok
Doctor :  
Donot read too much
User :   ok
User :  
haha
User :  
later
Doctor :   Later you can study

Doctor :   Thanks for consulting HealthcareMagic. Bye for now. Please refer your friends to our service.

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