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DNA analysis and blood grouping - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: General Health
Answered by

General & Family Physician
Practicing since : 2009
Answered : 594 Questions
User :   I am O positive blood type and My husband is AB positive. Our son's hospital record states he is O positive also. How is this possible? Is it possible that I am hh antigen system blood type (bombay blood type)? and so is my son? (I am ethnically Indian)
There is no chance of infidelity. There is no question and 0 doubt that my husband is not the father of my son. I have always been committed to him.
Please help, I'm really distressed.
Doctor :   hi
Doctor :   let me read ur query
User :   Ok
Doctor :   may i know the age of your son ?
User :   3 years
Doctor :   when did you get to know about this blood grouping
User :   recently
Doctor :   can you give me a few minutes so that i can give you more exact details
User :   ok
Doctor :   the possibility of you having bombay blood group would have to be checked by blood tests
Doctor :   and if you and your son , having such rare blood group could be one of the reason
Doctor :   the other reason could be a mistake by the lab
User :   so u suggest we get my husband and son's blood tested again?
Doctor :   for proper confirmation, and to clear all doubts, you can get a dna analysis
Doctor :   this will be 100% proof that he is your son
Doctor :   blood group polymorphism can lead to some kind of issues in assessing parenthood
Doctor :   but DNA is the final proof of parentage
User :   I don't have any doubt he is mine and my husband's but this whole blood group this is very distressing.
Doctor :   i do understand the situation
Doctor :   but sometimes it may be difficult to get the blood tests to check for hh blood grouping as this is usually rare to check for them
Doctor :   and most labs would not have them
User :   but is i am bombay blood group, that explains why My son is O?
User :   if*
Doctor :   yes, it can cause such abnormal polymorphisms , if you have the bombay blood group
User :   what is the reason for bombay blood group?
User :   and why is this only in india?
Doctor :   hh is a rare blood group also called Bombay Blood group
Doctor :   Individuals with the rare Bombay phenotype (hh) do not express H antigen (also called substance H) (the antigen which is present in blood group O)
Doctor :   this initial pattern was obsereved in bombay, and research was done in people from bombay
Doctor :   hence the name fell as bombay blood group
Doctor :   i hope you have understood my advice,
Doctor :   do not beat yourself on this matter
Doctor :   a DNA analysis will help to clear all doubts
User :   yes I will talk to my husband and then go for dna testing
User :   thanks you so much
Doctor :   you can consult a hematologist , who can give you more insight on such abnormal blood groups
Doctor :   you are welcome
Doctor :   take care and have a good night
User :   you too
User :   good night
Doctor :   bye for now
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