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Beta thalessemia problem - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Blood Cancer(Leukemia)
Answered by

General & Family Physician
Practicing since : 2005
Answered : 2307 Questions
User :   Hi, My mother-in-law expired with acute myeloid leukemia, 4 ys back. I want to know what are the chances of my husband and son getting it? Are there any tests to detect it?
Doctor :   Hi
User :   Hello dr
Doctor :   Sure I will help you with that
User :   Thank You
User :   Are u there?
Doctor :   Plz wait
User :   Ok
Doctor :   i will be hr 24 hrs
User :   Are u an oncologist?
Doctor :   No
Doctor :   A hereditary risk for AML appears to exist
User :   ok
Doctor :   There are numerous reports of multiple cases of AML developing in a family at a rate higher than predicted by chance alone.
Doctor :   The risk of developing AML is increased threefold in first-degree relatives of patients with AML
Doctor :   First degree relative mean here immediate family member
User :   st degree would include my husband and son?
User :   *first
Doctor :   This just the family history
User :   Another thing they both suffer from beta thalassemia minor
Doctor :   Does your mother-in-law had any other problems?
Doctor :   Both means?
User :   Husband and son
Doctor :   ok
User :   She was not keeping well....frequent ulcer in the mouth which never healed
Doctor :   You Beta thalaseemia is genetic abnormality
Doctor :   I am asking whether she had any other cancers ,
User :   no she was detected only with that
Doctor :   was she exposed to any chemical s or radiation?
Doctor :   Ok
User :   no age didnot permit
User :   to gv radiation/chjemo
User :   *chemo
Doctor :   ok
Doctor :   So yes
Doctor :   there is some increases risk of AML
Doctor :   in family memmbers
User :   so what can be done to detect it early?
Doctor :   very good Q
User :   its a worry which is always in my mind...
Doctor :   there are no special tests recommended to detect acute myeloid leukemia (AML) early
Doctor :   The best way to find leukemia early is to report any possible symptoms of leukemia
User :   any specific symptoms to look for?
Doctor :   regular medical checkups and regular blood work will help
Doctor :   These can include weight loss, fatigue, fever, night sweats, and loss of appetite.
User :   what are the checkups? how soon they should be done?
User :   I get their blood work done every 6 mnths
Doctor :   Most signs and symptoms of AML result from a shortage of normal blood cells, which happens when the leukemia cells crowd out the normal blood-making cells in the bone marrow. As a result, people do not have enough normal red blood cells, white blood cells, and blood platelets. These shortages show up on blood tests, but they can also cause symptoms.
Doctor :   Anemia is a shortage of red blood cells. It can cause a person to feel tired, weak, cold, dizzy, or lightheaded, and can cause headaches and shortness of breath
Doctor :   A shortage of normal white blood cells (leukopenia) increases the risk of infections
Doctor :   A shortage of blood platelets (thrombocytopenia) can lead to excess bruising, bleeding, frequent or severe nosebleeds, and bleeding gums.
Doctor :   check up mean physical examination's and CBC with differential count
User :   that is general health check up by a GP and blood work, right?
Doctor :   Yes it is
Doctor :   There are no special tests
User :   How often should I do it?
Doctor :   there is no fixed regimen accordingto science
Doctor :   I think 6 mo will be ok
Doctor :   you have to tell the physican the reason for physicals
User :   ok
Doctor :   And ask him to do the Complete blood count and peripheral blood smear
Doctor :   simple blood tests will detect it
Doctor :   There are usually very high white cells in blood count
User :   cbc peripheral...ya they are always done
Doctor :   good
Doctor :   remeber the words
Doctor :   Do u have any questions?
Doctor :   raise the Q
Doctor :   in peripheral smear u see big cells
User :   so what i summarize is physicals and blood work including peripherals blood smear and cbc, every 6 months, right?
Doctor :   in cbc u see many white cells
User :   ok
User :   ok
Doctor :   That is good
User :   thank you....i think i am going the right way, till now....another thing my husband has high uric acid
User :   any relation?
Doctor :   it is non speficifc
User :   ok
Doctor :   do not get confuded with the present concept of cbc and peripheral smaer
Doctor :   uric acid is achemical
User :   should these tests be done for my son also...he will be 5 next week
Doctor :   it increases with high ptotein intake, dehyadration,
User :   yes i am aware of that
User :   his protein intake has been reduced
Doctor :   No
Doctor :   ur son will be 5 mo next wk
User :   sorry 5 ys
Doctor :   ok
Doctor :   There are no protocols to screen
Doctor :   but what we have discussed
Doctor :   is let us get them done every mo
Doctor :   so let us stick to that
User :   every month or 6 monthly
Doctor :   6 mo or 1 yr
User :   ok
Doctor :   whichever u feel good
Doctor :   but any symptoms need urgent check up
Doctor :   fatigue, tiredness, high fever, any bleeding
Doctor :   >>>> get CBC, P smear
User :   1 yr is fine....then i will get it done in 1 year......both for my son and husband...and surely i will adhere to your advice
Doctor :   good
User :   Thank you for your advice
Doctor :   Thank you
Doctor :   Take care
Doctor :   Bye
User :   Bye
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