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Autoimmune disease - Online Doctor Chats

Date : 21-Feb-2012
User rating for this question
Very Good Posted in: Kidney Conditions
Answered by

General & Family Physician
Practicing since : 2004
Answered : 1722 Questions
User :   Hi I am a 37 year old female. I am trying to determine if there is a causitive link between asbetoes exposure from my workplace and my diagnosis of IgA Nephropathy.
Doctor :   Hi
User :   Nice to meet you
Doctor :   Nice to meet you too
User :   I am trying to determine two things: if there is a link between my exposure to asbestoes and my diagnosis of IgA Nephropathy and whether or not I could have reduced the amount of damage caused to my kidney's (1/4 lost) because onset of symptoms was in 2001 (idiopathic edema both legs and blood in urine) and diagnosis in 2006 with biopsy.
Doctor :   No , there is no link between asbestos and Ig A nephropathy
Doctor :   Can you redefine your second question ?
User :   I had symptoms of leg edema and hematuria in 2001 and 2003. I had asked to have a follow up done. The only thing done was a referral to an internist who determined that the edema was idiopathic. There were no further tests or blood work done. When the hematuria returned in 2005, more extensive workup was done and portinuria was found as well ans increased creatin. What I am curious about is would it have been found earlier if it had been persued at an earlier date? When the biopsy was done I have found out that I had lost the finction of 1/4 of each kidney.
Doctor :   yes, with a detailed study and integrated approach with an nephrologist and a n immunologist the condition would have been found out in earlier times itself , and hence the disease process would have been slowed
User :   I have been reading several articles about how researchers have been finding a link between autoimmune diseases and asbestoes exposure, would this not include IgA Nephropathy?
Doctor :   It could be considered as immune response to the asbestos than an autoimmunity
Doctor :   and the complications of asbestoses are mostly restricted to lungs
User :   Thank you I have a better understanding. So the IgA could have been my bodies autoimmune reaction to my exposure to the asbetoes that I was exposed to?
Doctor :   no , you got it wrong
Doctor :   i meant the autoimmunity is one type of immunity where the body's defense mechanism acts on own tissues and proteins
Doctor :   no material do stimulate it
Doctor :   if it is due to asbestos it would be specific immune response against asbestos
Doctor :   ans most of times asbestos related complications or immune response related illnesses are restricted to lungs
Doctor :   and*
Doctor :   autoimmune response is not triggered by any foreign material
Doctor :   autoimmunity will commonly be due to inherent properties like defective genes, chromosomal abnormality , abnormal antibodies , etc
User :   The next question is, what if there is no family history, no defective genes, and I was also found to have normal levels of IgA, what other causes are there for IgA?
Doctor :   the familial cause can be excluded unless proved
Doctor :   as some people may go without symptoms or the disease even when they carry the defective genes
Doctor :   its not that they have to have Ig A nephropathy only , any kind of autoimmunity in the parents would be a clue point
User :   So then the only real possibility I had was trying to have the ephropathy diagnosed earlier in order to have it stabalized sooner.
Doctor :   yes,
User :   As someone who was a sufferer of bronchitis as a child, and chest infections later as an adult, would these infections have been exacerbated by diesel fumes and exposure to asbestoes?
User :   and would these conditions as well as the Nephropathy have been further exacerbated by severe stress?
Doctor :   could be a rare chance , but cant be proved practically
Doctor :   since the immune response in the lungs is carried by I a immunoglobulin for some extent the possibility can be rated as rare
User :   rare but possible to occur?
Doctor :   hard to say , yes ( theoretical )
User :   Dr Raju, can ask what your specialty is? You have been able to answer so many of my question this evening and help me understand what I have.
Doctor :   I am a general practitioner
Doctor :   i see you have asked for a specialist opinion to one of our nephrologist , once you get the answer come on to the chat , we can have a detailed discussion over it
User :   That sounds wonderful. I am always wary of the many articles that I read and want to make sure that I have the most up to date information.
Doctor :   sure i will help you with that
User :   Thank you very much. Have a great evening.
Doctor :   you are welcome ,
Doctor :   thanks for consulting me , kindly provide your feedback
User :   I will.
Doctor :   Bye for now
Doctor :   Take care
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